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Table S1: Sports participation according to type of sport played within the asymptomatic control (CON) group and the symptomatic anterior cruciate ligament (ACL) rupture group, for all male and female participants.

Table S2: Characteristics of the asymptomatic control (CON) group, the anterior cruciate ligament (ACL) rupture group and the ACL subgroup with a noncontact (NON) mechanism of injury.

Table S3: Genotype effects on descriptive measures for the VEGFA rs699947, VEGFA rs1570360, VEGFA rs2010963, KDR rs2071559, KDR rs1870377, NGFB rs6678788, and HIF1A rs11549465 polymorphisms in the South African Caucasian population.

Table S4: Injury profiles of the male and female participants in the asymptomatic control (CON), anterior cruciate ligament (ACL) rupture groups, and the ACL subgroup with a noncontact (NON) mechanism of injury.

Table S5: Genotype and minor allele frequency distributions, and p-values for Hardy-Weinberg exact test of the polymorphisms investigated in the VEGFA, KDR, NGFB, and HIF1A genes in the male controls (CON), the male anterior cruciate ligament (ACL) rupture group and the male ACL subgroup with a noncontact (NON) mechanism of injury within the South African Caucasian population.

Table S6: Genotype and minor allele frequency distributions, and p-values for Hardy–Weinberg exact test of the polymorphisms investigated in the VEGFA, KDR NGFB, and HIF1A genes in the female controls (CON), the female anterior cruciate ligament (ACL) rupture group and the female ACL subgroup with a noncontact (NON) mechanism of injury within the South African Caucasian population.

Figure S1: Schematic representation of the A) vascular endothelial growth factor A (VEGFA), B) kinase-insert domain receptor (KDR), C) nerve growth factor beta (NGFB), and D) hypoxia-inducible factor alpha 1 subunit (HIF1A) genes depicting the polymorphisms investigated. The sizes and location of the gene are shown under the gene name.

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