Research Article

Adhesive tablet effective for treating canker sores in humans

  1. Boaz Mizrahi1,
  2. Jacob Golenser2,
  3. Joseph S. Wolnerman3,
  4. Abraham J. Domb1,*

Article first published online: 29 SEP 2004

DOI: 10.1002/jps.20193

Issue

Journal of Pharmaceutical Sciences

Journal of Pharmaceutical Sciences

Volume 93, Issue 12, pages 2927–2935, December 2004

Additional Information

How to Cite

Mizrahi, B., Golenser, J., Wolnerman, J. S. and Domb, A. J. (2004), Adhesive tablet effective for treating canker sores in humans. Journal of Pharmaceutical Sciences, 93: 2927–2935. doi: 10.1002/jps.20193

Author Information

  1. 1

    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, the Hebrew University of Jerusalem, Jerusalem 91120, Israel

  2. 2

    Department of Parasitology, School of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel

  3. 3

    Department of Oral Medicine, Alyn Hospital, Jerusalem, Israel

*Department of Medicinal Chemistry and Natural Products, School of Pharmacy, the Hebrew University of Jerusalem, Jerusalem 91120, Israel. Telephone: 972-2-6757574; Fax: 972-2-6758959

Publication History

  1. Issue published online: 29 SEP 2004
  2. Article first published online: 29 SEP 2004
  3. Manuscript Accepted: 21 JUN 2004
  4. Manuscript Revised: 18 JUN 2004
  5. Manuscript Received: 24 FEB 2004

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Keywords:

  • controlled release;
  • mucosal delivery;
  • buccal;
  • polymers

Abstract

A new mucoadhesive tablet, which releases natural active agents for pain reduction and rapid healing of canker sores, has been prepared and characterized. Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and hydroxypropyl cellulose, absorbed with citrus oil and magnesium salt. The rate of tablet erosion and the rates of citrus oil and magnesium release were determined as well as the adhesiveness of the tablet using bovine gingival tissue and an Instron tensiometer. A clinical trial was conducted on 248 volunteers who had canker sores. Tablets adhere well to the mucosal tissue and gradually erode for 8 h releasing the citrus oil in a zero-order pattern whereas the magnesium is released during a period of 2 h. Both experimental and plain tablets were effective in reducing pain and decreasing healing time (p < 0.05) without adverse side effects. However, the tablets loaded with active agents were more effective. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:2927–2935, 2004

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