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Iontophoretic transdermal delivery of sumatriptan: Effect of current density and ionic strength

Authors

  • A. Femenía-Font,

    1. Departamento de Fisiología, Farmacología y Toxicología, Universidad Cardenal Herrera-CEU, 46113 Moncada, Spain
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  • C. Balaguer-Fernández,

    1. Departamento de Fisiología, Farmacología y Toxicología, Universidad Cardenal Herrera-CEU, 46113 Moncada, Spain
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  • V. Merino,

    1. Departament de Farmàcia i Tecnologia Farmacèutica, Universitat de València, 46100 Burjassot, Spain
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  • A. López-Castellano

    Corresponding author
    1. Departamento de Fisiología, Farmacología y Toxicología, Universidad Cardenal Herrera-CEU, 46113 Moncada, Spain
    • Departamento de Fisiología, Farmacología y Toxicología, Universidad Cardenal Herrera-CEU, 46113 Moncada, Spain Telephone: 34 96 1369000 Ext.: 1139; Fax: 34 961395272.
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Abstract

Iontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273 ± 83 nmol/cm2 h. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:2183–2186, 2005

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