Semisolid systems containing propolis for the treatment of periodontal disease: In Vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties

Authors

  • Marcos L. Bruschi,

    Corresponding author
    1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Zeferino Vaz, s/n, CEP 14040-903, Ribeirão Preto, SP, Brazil
    • Av. Colombo, nº 5790, Câmpus Universitário, Maringá, Paraná, Brazil, CEP 87020-900; Telephone: 55 44 3261-4817; Fax: 55 44 3261-4999.
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  • David S. Jones,

    1. School of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
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  • Heitor Panzeri,

    1. Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
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  • Maria P.D. Gremião,

    1. Faculdade de Ciências Farmacêuticas de Araraquara, Universidade Estadual Paulista, Araraquara, SP, Brazil
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  • Osvaldo de Freitas,

    1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Zeferino Vaz, s/n, CEP 14040-903, Ribeirão Preto, SP, Brazil
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  • Elza H.G. Lara

    1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Zeferino Vaz, s/n, CEP 14040-903, Ribeirão Preto, SP, Brazil
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Abstract

Formulations containing poloxamer 407 (P407), carbopol 934P (C934P), and propolis extract (PE) were designed for the treatment of periodontal disease. Gelation temperature, in vitro drug release, rheology, hardness, compressibility, adhesiveness, mucoadhesion, and syringeability of formulations were determined. Propolis release from formulations was controlled by the phenomenon of relaxation of polymer chains. Formulations exhibited pseudoplastic flow and low degrees of thixotropy or rheopexy. In most samples, increasing the concentration of C934P content significantly increased storage modulus (G′), loss modulus (G″), and dynamic viscosity (η′), at 5°C, G″ exceeded G′. At 25 and 37°C, η′ of each formulation depended on the oscillatory frequency. Formulations showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 34–37°C. Increasing the C934P content or temperature significantly increased formulation hardness, compressibility, and adhesiveness. The greatest mucoadhesion was noted in the formulation containing 15% P407 (w/w) and 0.25% C934P (w/w). The work of syringeability values of all formulations were similar and very desirable with regard to ease of administration. The data obtained in these formulations indicate a potentially useful role in the treatment of periodontitis and suggest they are worthy of clinical evaluation. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:2074–2089, 2007

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