Molecular aspects of phytoestrogen selective binding at estrogen receptors

Authors

  • Joseph V. Turner,

    Corresponding author
    1. School of Medicine, Rural Clinical Division, The University of Queensland, Locked Bag 9009, Toowoomba DC, Brisbane, QLD 4350, Australia
    • School of Medicine, Rural Clinical Division, The University of Queensland, Locked Bag 9009, Toowoomba DC, Brisbane, QLD 4350, Australia. Telephone: 61-7-4616 6670/Mobile: 61-419 143 154; Fax: 61-7-4616 6671.
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  • Snezana Agatonovic-Kustrin,

    1. School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia
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  • Beverley D. Glass

    1. School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia
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Abstract

Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. An increase in phytoestrogen research over the past few decades has demonstrated the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. Identification of the estrogen receptor β (ERβ) and research into various ligand classes has enabled elucidation of molecular aspects important in selective ER binding. This article explores the structural characteristics and significance of functional groups as they relate to phytoestrogen selectivity for ER binding. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:1879–1885, 2007

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