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Review
Skin peptides: Biological activity and therapeutic opportunities
Article first published online: 3 OCT 2007
DOI: 10.1002/jps.21198
Copyright © 2007 Wiley-Liss, Inc.
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
Additional Information
How to Cite
Namjoshi, S., Caccetta, R. and Benson, H. A. (2008), Skin peptides: Biological activity and therapeutic opportunities. Journal of Pharmaceutical Sciences, 97: 2524–2542. doi: 10.1002/jps.21198
Publication History
- Issue published online: 29 MAY 2008
- Article first published online: 3 OCT 2007
- Manuscript Accepted: 15 AUG 2007
- Manuscript Revised: 13 AUG 2007
- Manuscript Received: 14 MAY 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- antimicrobial peptides;
- wound healing;
- psoriasis;
- dermatitis;
- dermatology;
- cosmeceutical
Abstract
The skin provides an effective barrier to the loss of body fluids and environmental assault. In addition to the physical barrier provided by the stratum corneum, the skin also contains a chemical barrier consisting of antimicrobial peptides (AMPs), which control microbial growth on the surface. These AMPs also have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing cell proliferation, wound healing, cytokine/chemokine production and chemotaxis. This review describes the range of peptides found in the skin, both constitutive and those induced in response to injury. The role these peptides play in normal skin function and in various skin conditions is described. A better understanding of their role in normal and skin disease may offer new strategies in skin disease, dermatology and as cosmeceuticals. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:2524–2542, 2008