Novel biodegradable blend matrices for controlled drug release

  1. Mei Lin1,2,
  2. Sheng Meng1,
  3. Wei Zhong1,*,
  4. Zhulai Li2,
  5. Qiangguo Du1,*,
  6. Piotr Tomasik3

Article first published online: 12 FEB 2008

DOI: 10.1002/jps.21297

Issue

Journal of Pharmaceutical Sciences

Journal of Pharmaceutical Sciences

Volume 97, Issue 10, pages 4240–4248, October 2008

Total views since August 2010: 164

Additional Information

How to Cite

Lin, M., Meng, S., Zhong, W., Li, Z., Du, Q. and Tomasik, P. (2008), Novel biodegradable blend matrices for controlled drug release. J. Pharm. Sci., 97: 4240–4248. doi: 10.1002/jps.21297

Author Information

  1. 1

    Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, China

  2. 2

    School of Pharmacy, Fujian Medical University, Fuzhou 350004, China

  3. 3

    Department of Chemistry, Agricultural University, Mickiewicz Ave. 21, 31-120 Cracow, Poland

*Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, China. Telephone: +86-21-65642392; Fax: +86-21-65640293.

Publication History

  1. Issue published online: 28 AUG 2008
  2. Article first published online: 12 FEB 2008
  3. Manuscript Accepted: 24 NOV 2007
  4. Manuscript Revised: 28 AUG 2007
  5. Manuscript Received: 8 MAY 2007

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Keywords:

  • biodegradable polymers;
  • controlled release;
  • ibuprofen;
  • phosphorylcholine;
  • poly-ε-caprolactone

Abstract

Phosphorylcholine-functionalized poly-ε-caprolactone (PC–PCL) is a new biodegradable polymer with good biocompatibility. In this study modulation of the controlled release of Ibuprofen (IB), a model drug, from poly-ε-caprolactone (PCL) by direct blending with PC–PCL is investigated. The influence of several factors such as the content of PC–PCL in the blend, drug loading and the molecular weight of PCL matrix upon the IB release is recognized. The release mechanism is discussed in terms of degradation/erosion profiles and hydrophilicity of the blend matrices. The IB release rate increased with the PC–PCL content because PC–PCL increased the hydrophilicity and biodegradability of the blends. Simultaneously, that release rate decreased with increase in the molecular weight of PCL in the blend. The drug loading in the blend also affected the release property of the matrix. Analysis of the release profiles following the power law indicated that the IB release was governed mainly by diffusion kinetics. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4240–4248, 2008

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