Chiral self assembled monolayers as resolving auxiliaries in the crystallization of valine

Authors

  • Aniruddh Singh,

    1. Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 W. 33rd St. Chicago, Illinois 60616
    Current affiliation:
    1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139.
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  • Allan S. Myerson

    Corresponding author
    1. Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 W. 33rd St. Chicago, Illinois 60616
    • Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 W. 33rd St. Chicago, Illinois 60616, Telephone: + 1 312 5673101; Fax: +1 312 5678857.
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Abstract

Chiral drugs are a subgroup of drug substances that contain one or more chiral centers. For reasons of safety and efficacy, the pure enantiomer is usually preferred over the racemate in many marketed dosage forms. Thus, resolution of racemic mixtures is an active area of research. In this work, chiral self assembled monolayers (SAMs) on gold were employed as resolving auxiliaries in the crystallization of the amino acid valine. Results showed the ability to obtain one enantiomer in excess on the crystals grown on the chiral SAMs when starting with racemic solutions. The enantiomer obtained in excess was the one having opposite chirality to the monolayer being used. In addition, it was possible to obtain crystals of the pure enantiomer when starting with a solution having an enantiomeric excess value of 50%. Control experiments carried out without chiral SAMs showed that at equilibrium, mixtures of the pure enantiomer and racemic compound were obtained under these conditions. The enantiomer obtained on the chiral SAMs was the one that was initially present in excess regardless of the chirality of the monolayer being used. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3931–3940, 2010

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