Commentary

Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

  1. Wim Jiskoot1,*,
  2. Theodore W. Randolph2,
  3. David B. Volkin3,
  4. C. Russell Middaugh3,
  5. Christian Schöneich3,
  6. Gerhard Winter4,
  7. Wolfgang Friess4,
  8. Daan J. A. Crommelin5,
  9. John F. Carpenter6

Article first published online: 14 DEC 2011

DOI: 10.1002/jps.23018

Issue

Journal of Pharmaceutical Sciences

Journal of Pharmaceutical Sciences

Volume 101, Issue 3, pages 946–954, March 2012

Total views since publication: 2234

Additional Information

How to Cite

Jiskoot, W., Randolph, T. W., Volkin, D. B., Middaugh, C. R., Schöneich, C., Winter, G., Friess, W., Crommelin, D. J. A. and Carpenter, J. F. (2012), Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release. J. Pharm. Sci., 101: 946–954. doi: 10.1002/jps.23018

Author Information

  1. 1

    Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden 2300 RA, the Netherlands

  2. 2

    Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, University of Colorado Boulder, Boulder, Colorado 80309

  3. 3

    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047

  4. 4

    Department of Pharmacy, Ludwig Maximilians Universität München, Munich 81377, Germany

  5. 5

    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

  6. 6

    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045

*Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden 2300 RA, the Netherlands. Telephone: +31-71-5274314; Fax: +31-71-5274565

Publication History

  1. Issue published online: 13 JAN 2012
  2. Article first published online: 14 DEC 2011
  3. Manuscript Accepted: 30 NOV 2011
  4. Manuscript Revised: 22 NOV 2011
  5. Manuscript Received: 27 SEP 2011

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Publication date: 14 Dec 2011. Cumulative views from 14 Dec 2011 - 22 May 2013.

  • Total views: 2234
  • Total PDF views: 1744
  • Total HTML views: 490

Cumulative Usage:

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Nov 201100
Dec 2011677
Jan 201217424
Feb 2012997210
Mar 20121086234
Apr 20121245279
May 20121353322
Jun 20121423353
Jul 20121450363
Aug 20121480367
Sep 20121516374
Oct 20121553394
Nov 20121591412
Dec 20121624420
Jan 20131651428
Feb 20131676445
Mar 20131698461
Apr 20131730481
May 20131744490
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