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Keywords:

  • vaccines;
  • stability;
  • global health;
  • dose proportionality;
  • vaccine adjuvants

Abstract

A number of product development partnerships are actively developing new vaccines to combat infectious diseases in developing countries. To be effective, the products under development should not only be safe, efficacious, and affordable, but they should also have additional desirable technical attributes, including enhanced stability, efficient packaging, and improved ease of delivery. New technologies are now available to achieve these attributes; however, many of the technologies have yet to be adopted by the vaccine industry. This commentary discusses the opportunities and challenges associated with advancing such attributes, especially vaccine thermostability and dose sparing strategies, and the critical issues that must be addressed to bridge the gap between technology development and product development. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:29–33, 2013