Tablet Disintegration Studied by High-Resolution Real-Time Magnetic Resonance Imaging

Authors

  • Julian Quodbach,

    1. Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
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  • Amir Moussavi,

    1. Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Goettingen, Germany
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  • Roland Tammer,

    1. Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Goettingen, Germany
    2. Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Goettingen, Germany
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  • Jens Frahm,

    1. Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Goettingen, Germany
    2. Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Goettingen, Germany
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  • Peter Kleinebudde

    Corresponding author
    1. Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
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Abstract

The present work employs recent advances in high-resolution real-time magnetic resonance imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A temporal resolution of 75 ms and a spatial resolution of 80 × 80 μm with a section thickness of only 600 μm were achieved. The histograms of MRI videos were quantitatively analyzed with MATLAB. The mechanisms of action of six commercially available disintegrants, the influence of relative tablet density, and the impact of disintegrant concentration were examined. Crospovidone seems to be the only disintegrant acting by a shape memory effect, whereas the others mainly swell. A higher relative density of tablets containing croscarmellose sodium leads to a more even distribution of water within the tablet matrix but hardly impacts the disintegration kinetics. Increasing the polacrilin potassium disintegrant concentration leads to a quicker and more thorough disintegration process. Real-time MRI emerges as valuable tool to visualize and investigate the process of tablet disintegration. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:249–255, 2014

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