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Keywords:

  • nanoparticles;
  • ophthalmic carriers;
  • polymeric biomaterials;
  • poly (acrylic acid);
  • poly (ethylene glycol) four arms amine terminated;
  • formulation;
  • w/o emulsion;
  • biocompatibility;
  • controlled release/delivery

Poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG), four-arm, amine-terminated particles with nanometer size and spherical shape were obtained by the polymers cross-linking, via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride, in a w/o emulsion. The morphology and surface charge of the final particles are strongly dependent on the molar ratio of PAA–PEG and the PAA concentration. The physicochemical characteristics correlated with the drug-loading capacity, in vitro and ex vivo release kinetics of pilocarpine hydrochloride and biocompatibility results indicate that these nanoparticles exhibit the prerequisite behavior for use as carriers of ophthalmic drugs. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:676–686, 2014