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Abstract

A new method for the evaluation of central nervous system depression is presented. It is based on the scoring of behavioral responses to subhypnotic doses of central depressants. The application of the method to the study of two different types of depressants, pentobarbital and chlorpromazine, both alone and in combination, is shown. The time-response scoring method appears to be useful as a screening method and as a tool for more theoretical studies when appropriate modifications are made for different types of pharmacological agents.