Method for evaluating behavioral effects of central depressants
Article first published online: 21 SEP 2006
Copyright © 1964 Wiley-Liss, Inc., A Wiley Company
Journal of Pharmaceutical Sciences
Volume 53, Issue 8, pages 863–868, August 1964
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How to Cite
Cohen, M. and Nelson, J. W. (1964), Method for evaluating behavioral effects of central depressants. J. Pharm. Sci., 53: 863–868. doi: 10.1002/jps.2600530803
- Issue published online: 21 SEP 2006
- Article first published online: 21 SEP 2006
- Manuscript Accepted: 11 DEC 1963
- Manuscript Received: 15 JUL 1963
- PHS. Grant Number: MY-2929
- National Institute of Mental Health, U. S. Public Health Service, Bethesda, Md.
A new method for the evaluation of central nervous system depression is presented. It is based on the scoring of behavioral responses to subhypnotic doses of central depressants. The application of the method to the study of two different types of depressants, pentobarbital and chlorpromazine, both alone and in combination, is shown. The time-response scoring method appears to be useful as a screening method and as a tool for more theoretical studies when appropriate modifications are made for different types of pharmacological agents.