Metabolism of morphine by cats

Authors

  • S. Y. Yeh,

    1. Department of Pharmacology' College of Medicine, University of Iowa, Iowa City, IA 52240
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  • H. I. Chernov,

    1. Department of Pharmacology' College of Medicine, University of Iowa, Iowa City, IA 52240
    Current affiliation:
    1. Ciba Pharmaceutical Co., Summit, N.J.
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  • L. A. Woods

    1. Department of Pharmacology' College of Medicine, University of Iowa, Iowa City, IA 52240
    Current affiliation:
    1. Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23219
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Abstract

Cats excreted 19.2 ± 1.5% of free morphine and 48.4 ± 2.4% of conjugated morphine in urine during the first 48 hr. after subcutaneous injection of morphine. Fecal excretion during 2 days following drug administration ranged from 2.0 to 20% of the injected drug. The major morphine conjugate was isolated and characterized as morphine-3-ethereal sulfate by UV and IR spectra, morphine content, and elemental analysis. In addition to morphine-3-ethereal sulfate, morphine-3-glucuronide and normorphine were also identified as minor metabolites.

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