Research Article

Absorption kinetics of aspirin in man following oral administration of an aqueous solution

  1. Malcolm Rowland1,*,
  2. Sidney Riegelman1,
  3. Phillip A. Harris1,†,
  4. Stephen D. Sholkoff2,*

Article first published online: 17 SEP 2006

DOI: 10.1002/jps.2600610312

Issue

Journal of Pharmaceutical Sciences

Journal of Pharmaceutical Sciences

Volume 61, Issue 3, pages 379–385, March 1972

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Additional Information

How to Cite

Rowland, M., Riegelman, S., Harris, P. A. and Sholkoff, S. D. (1972), Absorption kinetics of aspirin in man following oral administration of an aqueous solution. J. Pharm. Sci., 61: 379–385. doi: 10.1002/jps.2600610312

Author Information

  1. 1

    Department of Pharmacy, School of Pharmacy, School of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94122

  2. 2

    Rheumatic Disease Group, Department of Medicine, School of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94122

  1. †

    School of Pharmacy, University of Southern California, Los Angeles, Calif

*Department of Pharmacy, School of Pharmacy, School of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94122

Publication History

  1. Issue published online: 17 SEP 2006
  2. Article first published online: 17 SEP 2006
  3. Manuscript Accepted: 10 NOV 1971
  4. Manuscript Received: 27 AUG 1969

Funded by

  • National Institutes of Health, U. S. Public Health Service. Grant Numbers: NIGMS 16494, 2A-5124

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Keywords:

  • Aspirin, oral—absorption kinetics, aqueous solution, man;
  • Absorption kinetics—aspirin, oral aqueous solution, man;
  • Pharmacokinetics, aspirin, oral aqueous solution—absorption kinetics, calculations, half-life, plasma concentrationtime curves, two-compartment model;
  • Half-life—orally administered aspirin, first-order kinetics, man

Abstract

The absorption of aspirin was studied in four male subjects following an oral solution of 650 mg. The absorption process appeared to follow first-order kinetics, with a half-life ranging from 4.5 to 16.0 min. between subjects. Comparison of the area under the aspirin plasma concentration-time curve following intravenous and oral routes indicated that only 68% of the dose reached the peripheral circulation intact. A two-compartment model for both aspirin and its metabolite, salicylic acid, involving a constant fractional hydrolysis of aspirin during absorption, satisfactorily described both the aspirin and resultant salicylic acid plasma data. Methods used to calculate aspirin absorption kinetics are discussed.

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