Effect of sodium taurodeoxycholate on biological membranes: Release of phosphorus, phospholipid, and protein from everted rat small intestine



Sodium taurodeoxycholate accelerates the release of total phosphorus, lipid phosphorus, and protein from isolated everted rat small intestinal sacs. The effect occurs at concentrations of the physiological surfactant above the CMC. The effect of sodium taurodeoxycholate on components of the biological membrane can be related to an increase in permeability of the everted intestine to phenol red in the presence of various concentrations of the surfactant. The interaction of the surfactant with the biological membrane may produce an acceleration of the loss of structural integrity of the preparation, resulting in an increased permeability to phenol red.