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Symposium
Drug-biomolecule interactions: Interactions of mononucleotides and polybasic amino acids
Article first published online: 17 SEP 2006
DOI: 10.1002/jps.2600640335
Copyright © 1975 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
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How to Cite
Lacey, J. C. and Pruitt, K. M. (1975), Drug-biomolecule interactions: Interactions of mononucleotides and polybasic amino acids. J. Pharm. Sci., 64: 473–477. doi: 10.1002/jps.2600640335
Publication History
- Issue published online: 17 SEP 2006
- Article first published online: 17 SEP 2006
Keywords:
- Mononucleotides—interactions with polybasic amino acids;
- Amino acids, polybasic—interactions with mononucleotides;
- Drug-biomolecule interactions—mononucleotides and polybasic amino acids;
- Interactions—drugs with biomolecules, symposium
Abstract
Histones and ribosomal proteins are basic proteins that participate in gene regulation and protein synthesis, respectively. How these proteins interact with nucleic acids is not yet clear, although specificities in these interactions have been observed. Study of the interaction of mononucleotides with basic polyamino acids is one approach to understanding such interactions. The results of studies with the mononucleotides can help elucidate the normal molecular processes in biological systems and also shed light on some effects of drugs, such as puromycin and tubericidin, that are nucleotide derivatives. A review of studies on the interaction of mononucleotides and basic polyamino acids such as polylysine and polyarginine is presented. In addition, a short review of the self-associative properties of mononucleotides is given. Studies of the mononucleotide-polyamino acid interaction have involved a wide variety of techniques including equilibrium dialysis, NMR, optical rotatory dispersion, circular dichroism, and precipitate analysis.