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Sulfur analogs of psychotomimetic amines
Article first published online: 18 SEP 2006
DOI: 10.1002/jps.2600651040
Copyright © 1976 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
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How to Cite
Nichols, D. E. and Shulgin, A. T. (1976), Sulfur analogs of psychotomimetic amines. J. Pharm. Sci., 65: 1554–1556. doi: 10.1002/jps.2600651040
Publication History
- Issue published online: 18 SEP 2006
- Article first published online: 18 SEP 2006
- Manuscript Accepted: 24 DEC 1975
- Manuscript Received: 28 OCT 1975
Funded by
- General Research Support funds
Keywords:
- Amines, phenylalkyl, substituted—sulfur analogs of psychotomimetic agents synthesized;
- Sulfur analogs—psychotomimetic substituted phenylalkylamines synthesized;
- Psychotomimetic agents, potential—sulfur analogs of substituted phenylalkylamines synthesized
Abstract
The syntheses and physical properties are described for 2,5-dimethoxy-4-methylthiophenylethylamine and 2,5-dimethoxy-4-methylthiophenylisopropylamine. The latter compound is the sulfur analog of the psychotomimetic phenylisopropylamines 2,4,5-trimethoxyphenylisopropylamine and 2,5-dimethoxy-4-methylphenylisopropylamine wherein the methylthio group replaces a methoxy group or a methyl group, respectively. This compound is predicted to be about 30 times as active as mescaline.