Pharmacokinetics of propylene glycol in humans during multiple dosing regimens

Authors

  • Dale K. Yu,

    1. Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455
    Current affiliation:
    1. Biopharmaceutics Unit, Marion Laboratories, Inc., Kansas City, MO 64137
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  • William F. Elmquist,

    1. Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455
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  • Ronald J. Sawchuk

    Corresponding author
    1. Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455
    • Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455
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Abstract

The pharmacokinetics of propylene glycol has been examined during multiple oral-dosing regimens. The glycol is rapidly absorbed, with Cpmax observed within 1 h following administration. The terminal elimination half-life is ∼4 h. After a minimum of 10 half-lives of maintenance dosing on a fixed regimen, the accumulation of propylene glycol differed significantly among individuals because of variability in apparent clearance. The average apparent total body clearance is ∼0.1 L/kg · h and may be concentration dependent. The apparent volume of distribution is ∼0.5 L/kg, approximating total body water.

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