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Research Article
Inhibitory effects of procainamide and probenecid on renal excretion of sultopride enantiomers in rats
Article first published online: 21 SEP 2006
DOI: 10.1002/jps.2600821215
Copyright © 1993 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
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Additional Information
How to Cite
Kamizono, A., Inotsume, N., Fukushima, S., Nakano, M. and Okamoto, Y. (1993), Inhibitory effects of procainamide and probenecid on renal excretion of sultopride enantiomers in rats. J. Pharm. Sci., 82: 1259–1261. doi: 10.1002/jps.2600821215
Publication History
- Issue published online: 21 SEP 2006
- Article first published online: 21 SEP 2006
- Manuscript Accepted: 22 MAR 1993
- Manuscript Received: 16 SEP 1992
Abstract
The effects of the coadministration of procainamide and probenecid on the pharmacokinetic behavior of sultopride, an anti-psychotic agent, after intravenous administration were studied with rats. The areas under the concentration-time curve for and renal clearances of (+)-sultopride and (—)-sultopride, which exist as organic cations under physiological pH conditions, were significantly decreased (p < 0.01) by the coadministration of procainamide, an organic cation under physiological pH conditions. The renal clearance of (—)-sultopride was partially decreased (p < 0.05) by the coadministration of probenecid, an organic anion under physiological pH conditions. The results suggest that drug-drug interactions between organic cations and organic anions occur to a certain extent during the tubular secretion process in rats.