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Research Article
Comparative study of the two polymorphic forms of p-(1 R, 3S) 3-thioanisoyl-1, 2,2-trimethylcyclopentane carboxylic acid
Article first published online: 21 SEP 2006
DOI: 10.1002/jps.2600821216
Copyright © 1993 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
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Additional Information
How to Cite
Rambaud, J., Bouassab, A., Pauvert, B., Chevallet, P., Declercq, J.-P. and Terol, A. (1993), Comparative study of the two polymorphic forms of p-(1 R, 3S) 3-thioanisoyl-1, 2,2-trimethylcyclopentane carboxylic acid. J. Pharm. Sci., 82: 1262–1265. doi: 10.1002/jps.2600821216
Publication History
- Issue published online: 21 SEP 2006
- Article first published online: 21 SEP 2006
- Manuscript Accepted: 25 MAR 1993
- Manuscript Received: 6 OCT 1992
Abstract
The crystal structure of polymorph I of p-(1R, 3S)3-thioanisoyl-1, 2,2-trimethylcyclopentane carboxylic acid has been determined and is compared with that of polymorph II that was previously described. Polymorph I is very different at the level of the carboxyl group. It does not present disorder and the values found for the C-O bonds correspond exactly to single and double bond lengths. In addition, the carboxyl groups of the two molecules in the cell packing are involved in symmetric hydrogen bonds [2.662(6) Å] leading to the formation of a dimer around the twofold axis following x with a shift on z. The different conformations on the carboxylic group between the two polymorphs are in good agreement with the thermodynamic-study.