1520-6017/asset/JPS_left.gif?v=1&s=becd26fac43b87042ad04af68bbe20d6a12e64fc)
1520-6017/asset/olbannerright.jpg?v=1&s=254f44b422de0f476861bd1056a1789033e2171c)
Research Article
Necessary conditions for the π-electron delocalization in enamino-type muscle relaxants
Article first published online: 21 SEP 2006
DOI: 10.1002/jps.2600821220
Copyright © 1993 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
Total views since August 2010: 4
Additional Information
How to Cite
Cholli, A. L., Lau, M. L. and Gala, K. (1993), Necessary conditions for the π-electron delocalization in enamino-type muscle relaxants. J. Pharm. Sci., 82: 1275–1280. doi: 10.1002/jps.2600821220
Publication History
- Issue published online: 21 SEP 2006
- Article first published online: 21 SEP 2006
- Manuscript Accepted: 25 MAR 1993
- Manuscript Received: 16 NOV 1992
Abstract
Two necessary conditions have been proposed for the π-electron delocalization across four bonds in bis-quatemary bromides of enamino spiro-ketal-type compounds. Dynamic NMR data analysis of these compounds suggests that π-electron delocalization takes place if the first atom is nitrogen and the fourth atom is either nitrogen or oxygen [i.e., N+ ![[DOUBLE BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8fe.gif)
C — C N (or O)]. The second condition is that the end atoms of the four-bond system should not be the terminal group.