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Research Article
Controlled-release isosorbide dinitrate pellets. Part I: Design and evaluation of controlled-release capsule dosage form
Article first published online: 21 SEP 2006
DOI: 10.1002/jps.2600821223
Copyright © 1993 Wiley-Liss, Inc., A Wiley Company
1520-6017/asset/cover.gif?v=1&s=e589ccf35fd012c675e943835781318cb8666bed "Journal of Pharmaceutical Sciences")
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Additional Information
How to Cite
Lalla, J. K. and Bhat, S. U. (1993), Controlled-release isosorbide dinitrate pellets. Part I: Design and evaluation of controlled-release capsule dosage form. J. Pharm. Sci., 82: 1288–1291. doi: 10.1002/jps.2600821223
Publication History
- Issue published online: 21 SEP 2006
- Article first published online: 21 SEP 2006
- Manuscript Accepted: 25 FEB 1993
- Manuscript Received: 7 OCT 1991
Abstract
Design and evaluation of 8-h controlled-release isosorbide dinitrate capsules representing 20.0 and 40.0 mg of the drug are described. The formulation conforms to the total drug incorporated in the dosage form. In vitro dissolution studies indicate that the formulations behave as controlled-release dosage forms. Studies of storage at 30 ± 2 and 40 ± 2 °C at relative humidities of 72.0 and 90.0%, respectively, indicate that both temperature and humidity accelerate the degradation of the formulation. These results indicate the need of controlled packaging conditions during manufacture of these capsules.