Fellow of the American Foundation for Pharmaceutical Education. Present address: School of Pharmacy, The State College of Washington, Pullman.
Activity of jewelweed and its enzymes in the treatment of rhus dermatitis†
Article first published online: 28 SEP 2006
Copyright © 1950 Wiley-Liss, Inc., A Wiley Company
Journal of the American Pharmaceutical Association
Volume 39, Issue 5, pages 294–296, May 1950
How to Cite
Gibson, M. R. and Maher, F. T. (1950), Activity of jewelweed and its enzymes in the treatment of rhus dermatitis. J. Pharm. Sci., 39: 294–296. doi: 10.1002/jps.3030390516
A portion of a thesis submitted by Melvin R. Gibson to the Faculty of the Graduate College of the University of Illinois in partial fulfillment of the requirements for the degree of Doctor of Philosophy.
- Issue published online: 28 SEP 2006
- Article first published online: 28 SEP 2006
- Manuscript Received: 12 AUG 1949
In sensitized albino guinea pigs it was not possible to demonstrate therapeutic activity for jewelweed in poison ivy dermatitis after the outward manifestations became apparent. Neither was it possible to exhibit activity in limiting the biologic activity of poison ivy when poison ivy extracts and jewelweed juice were combined in vitro, or on the skin. This was attributable to a lesser degree of sensitivity in guinea pigs than in man and the greater amounts of ivy toxin necessary to elicit dermatitis exceeded the neutralizing powers of even concentrated preparations of jewelweed. In human subjects jewelweed was of no value in treating experimentally established dermatitis. Jewelweed juice or concentrated solutions of jewelweed enzymes were capable of inactivating more dilute poison ivy extracts when mixed in vitro and tested on human subjects under controlled conditions.