Journal of Pharmaceutical Sciences

Cover image for Vol. 100 Issue 11

November 2011

Volume 100, Issue 11

Pages 4563–5079

  1. Review

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Alternatives to conventional suspensions for pulmonary drug delivery by nebulisers: A review (pages 4563–4570)

      Amir Amani, Mohammad Ali Amini, Hany S.M. Ali and Peter York

      Version of Record online: 10 JUN 2011 | DOI: 10.1002/jps.22665

  2. Global Health Commentary

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. The global counterfeit drug trade: Patient safety and public health risks (pages 4571–4579)

      Tim K. Mackey and Bryan A. Liang

      Version of Record online: 22 JUN 2011 | DOI: 10.1002/jps.22679

  3. Rapid Communication

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Methylprednisolone-loaded PLGA microspheres: A new formulation for sustained release via intra-articular administration. A comparison study with methylprednisolone acetate in rats (pages 4580–4586)

      Alessia Panusa, Francesca Selmin, Giuseppe Rossoni, Marina Carini, Francesco Cilurzo and Giancarlo Aldini

      Version of Record online: 17 AUG 2011 | DOI: 10.1002/jps.22722

  4. Biotechnology

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation (pages 4587–4596)

      Bruce D. Mason, Le Zhang, Richard L. Remmele Jr. and Jifeng Zhang

      Version of Record online: 2 JUN 2011 | DOI: 10.1002/jps.22650

    2. Calcium binding to a factor ix Fc fusion protein and effects on higher-order structure (pages 4597–4606)

      Hao Li, Shufeng Bai, Julie Y. Wei, Steven A. Berkowitz and Mark L. Brader

      Version of Record online: 15 JUN 2011 | DOI: 10.1002/jps.22660

    3. Analytical characterization of a novel degradation product in a PEGylated recombinant protein (pages 4607–4616)

      Bing Zhang, Edward W. Towers, Leszek Poppe and Steven L. Cockrill

      Version of Record online: 6 JUN 2011 | DOI: 10.1002/jps.22661

    4. Impact of extractables/leachables from filters on stability of protein formulations (pages 4617–4630)

      Min Huang, Teresa S. Horwitz, Cindy Zweiben and Satish K. Singh

      Version of Record online: 21 JUN 2011 | DOI: 10.1002/jps.22670

    5. Qualification of FTIR spectroscopic method for protein secondary structural analysis (pages 4631–4641)

      Yijia Jiang, Cynthia Li, Xichdao Nguyen, Salman Muzammil, Ed Towers, John Gabrielson and Linda Narhi

      Version of Record online: 28 JUN 2011 | DOI: 10.1002/jps.22686

    6. Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near- and far-UV CD for protein higher order structural analysis (pages 4642–4654)

      Cynthia H. Li, Xichdao Nguyen, Linda Narhi, Letha Chemmalil, Edward Towers, Salman Muzammil, John Gabrielson and Yijia Jiang

      Version of Record online: 5 JUL 2011 | DOI: 10.1002/jps.22695

    7. The impact of decreased bead count to determine concentrations of amyloid beta1-42, total-tau, and phosphorylated-tau181 in human cerebrospinal fluid using xMAP technology (pages 4655–4663)

      Olaf Bjornstal, Kathryn Rogers, Wei Zhang, Richard Delhaye, Michele Malone, Steve Unger and William Nowatzke

      Version of Record online: 20 JUL 2011 | DOI: 10.1002/jps.22700

  5. Pharmaceutics, Preformulation and Drug Delivery

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Physical stability and recrystallization kinetics of amorphous ibipinabant drug product by fourier transform raman spectroscopy (pages 4687–4699)

      Wayne Sinclair, Michael Leane, Graham Clarke, Andrew Dennis, Mike Tobyn and Peter Timmins

      Version of Record online: 16 JUN 2011 | DOI: 10.1002/jps.22658

    2. Determination of the interaction between glimepiride and hyperbranched polymers in solid dispersions (pages 4700–4709)

      David Pahovnik, Sebastjan Reven, Jože Grdadolnik, Rok Borštnar, Janez Mavri and Ema Žagar

      Version of Record online: 8 JUN 2011 | DOI: 10.1002/jps.22662

    3. Particle aerosolisation and break-up in dry powder inhalers: Evaluation and modelling of the influence of grid structures for agglomerated systems (pages 4710–4721)

      William Wong, David F. Fletcher, Daniela Traini, Hak-Kim Chan, John Crapper and Paul M. Young

      Version of Record online: 21 JUN 2011 | DOI: 10.1002/jps.22663

    4. A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys (pages 4722–4733)

      Po-Chang Chiang, David C. Thompson, Sarbani Ghosh and Monique R. Heitmeier

      Version of Record online: 9 JUN 2011 | DOI: 10.1002/jps.22664

    5. Randomly methylated β-cyclodextrin derivatives enhance taxol permeability through human intestinal epithelial Caco-2 cell monolayer (pages 4734–4744)

      Ferenc Fenyvesi, Tímea Kiss, Éva Fenyvesi, Lajos Szente, Szilvia Veszelka, Mária A. Deli, Judit Váradi, Pálma Fehér, Zoltán Ujhelyi, Árpád Tósaki, Miklós Vecsernyés and Ildikó Bácskay

      Version of Record online: 9 JUN 2011 | DOI: 10.1002/jps.22666

    6. Potent enhancement of GFP uptake into HT-29 cells and rat skin permeation by coincubation with tat peptide (pages 4766–4773)

      Warangkana Lohcharoenkal, Aranya Manosaroi, Friedrich Götz, Rolf G. Werner, Worapaka Manosroi and Jiradej Manosaroi

      Version of Record online: 16 JUN 2011 | DOI: 10.1002/jps.22671

    7. Dimorphism of the prodrug l-tyrosine ethyl ester: Pressure–temperature state diagram and crystal structure of phase II (pages 4774–4782)

      Ivo B. Rietveld, Maria Barrio, Josep-Lluís Tamarit, Béatrice Nicolaï, Jacco Van de Streek, Nathalie Mahé, René Ceolin and Bernard Do

      Version of Record online: 22 JUN 2011 | DOI: 10.1002/jps.22672

    8. Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices (pages 4783–4789)

      Anna Argemí, Concepción Domingo, Ana Raquel Sampaio de Sousa, Catarina M. M. Duarte, Carlos A. García-gonzález and Javier Saurina

      Version of Record online: 24 JUN 2011 | DOI: 10.1002/jps.22684

    9. Improved dermal delivery of FITC–BSA using a combination of passive and active methods (pages 4804–4814)

      Qing Wang, Yuly A. Jaimes-Lizcano, Louise B. Lawson, Vijay T. John and Kyriakos D. Papadopoulos

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22687

    10. Functionalized lipid nanoparticles–cellophane hybrid films for molecular delivery: Preparation, physicochemical characterization, and stability (pages 4815–4822)

      M. Isabel Vázquez, Laura Peláez, Juana Benavente, J. Manuel López-Romero, Rodrigo Rico, Jesus Hierrezuelo, Elena Guillén and M. Rosa López-Ramírez

      Version of Record online: 28 JUN 2011 | DOI: 10.1002/jps.22688

    11. Drug release from HPMC matrices in milk and fat-rich emulsions (pages 4823–4835)

      Hywel D. Williams, Kevin P. Nott, David A. Barrett, Rob Ward, Ian J Hardy and Colin D. Melia

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/jps.22689

    12. Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water (pages 4836–4844)

      Ziyang Su, Suman Luthra, Joseph F. Krzyzaniak, Dena M. Agra-Kooijman, Satyendra Kumar, Stephen R. Byrn and Evgenyi Y. Shalaev

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22690

    13. Moisture content impacts the stability of DNA adsorbed onto gold microparticles (pages 4845–4854)

      Tyson J. Smyth, Jamie Betker, Wei Wang and Thomas J. Anchordoquy

      Version of Record online: 5 JUL 2011 | DOI: 10.1002/jps.22697

    14. Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer (pages 4855–4863)

      Tomoaki Kurosaki, Yumi Yamashita, Keisei Aki, Hitomi Harasawa, Hiroo Nakagawa, Yukinobu Kodama, Norihide Higuchi, Tadahiro Nakamura, Takashi Kitahara and Hitoshi Sasaki

      Version of Record online: 20 JUL 2011 | DOI: 10.1002/jps.22701

    15. Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs (pages 4864–4876)

      Michiel van Speybroeck, Randy Mellaerts, Thao Do Thi, Johan A. Martens, Jan Van Humbeeck, Pieter Annaert, Guy Van den Mooter and Patrick Augustijns

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/jps.22703

  6. Pharmaceutical Nanotechnology

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Synthesis and characterization of surface-modified PBLG nanoparticles for bone targeting: In vitro and in vivo evaluations (pages 4877–4887)

      İpek Özcan, Kawthar Bouchemal, Freimar Segura-Sánchez, Özgen Özer, Tamer Güneri and Gilles Ponchel

      Version of Record online: 22 JUN 2011 | DOI: 10.1002/jps.22678

  7. Pharmaceutical Technology

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Complementary near-infrared and raman chemical imaging of pharmaceutical thin films (pages 4888–4895)

      Jackeline I. Jérez Rozo, Anna Zarow, Bo Zhou, Rodolfo Pinal, Zafar Iqbal and Rodolfo J. Romañach

      Version of Record online: 7 JUN 2011 | DOI: 10.1002/jps.22653

    2. How molecular interactions affect crystal morphology: The case of haloperidol (pages 4896–4906)

      Giovanni Li Destri, Agostino Marrazzo, Antonio Rescifina and Francesco Punzo

      Version of Record online: 7 JUN 2011 | DOI: 10.1002/jps.22654

    3. Phase behavior of TPGS–PEG400/1450 systems and their application to liquid formulation: A formulation platform approach (pages 4907–4921)

      Jinjiang Li, Bei Yang, Jaquan Levons, Swathi Pinnamaneni and Krishnaswamy Raghavan

      Version of Record online: 8 JUN 2011 | DOI: 10.1002/jps.22659

    4. Advanced approach to build the design space for the primary drying of a pharmaceutical freeze-drying process (pages 4922–4933)

      Davide Fissore, Roberto Pisano and Antonello A. Barresi

      Version of Record online: 23 JUN 2011 | DOI: 10.1002/jps.22668

    5. Glass particles as an adjuvant: A model for adverse immunogenicity of therapeutic proteins (pages 4953–4964)

      Amber Haynes Fradkin, John F. Carpenter and Theodore W. Randolph

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22683

  8. Pharmacokinetics, Pharmacodynamics and Drug Metabolism

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach (pages 4965–4973)

      Kazuyoshi Yoshii, Masamichi Hirayama, Toshifumi Nakamura, Ryoko Toda, Junko Hasegawa, Mineo Takei, Yukinori Mera and Yoshihiro Kawabata

      Version of Record online: 31 MAY 2011 | DOI: 10.1002/jps.22649

    2. Development of a new permeability assay using low-efflux MDCKII cells (pages 4974–4985)

      Li Di, Carrie Whitney-Pickett, John P. Umland, Hui Zhang, Xun Zhang, David F. Gebhard, Yurong Lai, James J. Federico III, Ralph E. Davidson, Russ Smith, Eric L. Reyner, Caroline Lee, Bo Feng, Charles Rotter, Manthena V. Varma, Sarah Kempshall, Katherine Fenner, Ayman F. El-kattan, Theodore E. Liston and Matthew D. Troutman

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/jps.22674

    3. Effect of hyperlipidemia on ketoconazole–midazolam drug–drug interaction in rat (pages 4986–4992)

      Dalia A. Hamdy and Dion R. Brocks

      Version of Record online: 22 JUN 2011 | DOI: 10.1002/jps.22675

    4. Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions (pages 4993–5006)

      Mark A. Lovich, Abraham E. Wei, Mikhail Y. Maslov, Peter I. Wu and Elazer R. Edelman

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22681

    5. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein (pages 5007–5017)

      Ling Ye, Tao Wang, Lan Tang, Wei Liu, Zhen Yang, Juan Zhou, Zhijie Zheng, Zheng Cai, Ming Hu and Zhongqiu Liu

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22693

    6. Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3 (pages 5018–5030)

      Tom De Bruyn, Sarinj Fattah, Bruno Stieger, Patrick Augustijns and Pieter Annaert

      Version of Record online: 11 AUG 2011 | DOI: 10.1002/jps.22694

    7. An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione (pages 5048–5058)

      Hong-Zhen Yu, Si-Fei Han, Ping Li, Chun-Liu Zhu, Xin-Xin Zhang, Li Gan and Yong Gan

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/jps.22702

  9. Global Health

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Are counterfeit or substandard anti-infective products the cause of treatment failure in Papua New Guinea? (pages 5059–5068)

      Anita Nair, Stefanie Strauch, Jackson Lauwo, Richard W. O. Jähnke and Jennifer Dressman

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22691

  10. Note

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance (pages 5069–5077)

      Lisa M. Kaminskas, Victoria M. Mcleod, Christopher J. H. Porter and Ben J. Boyd

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/jps.22682

  11. Lessons Learned

    1. Top of page
    2. Review
    3. Global Health Commentary
    4. Rapid Communication
    5. Biotechnology
    6. Pharmaceutics, Preformulation and Drug Delivery
    7. Pharmaceutical Nanotechnology
    8. Pharmaceutical Technology
    9. Pharmacokinetics, Pharmacodynamics and Drug Metabolism
    10. Global Health
    11. Note
    12. Lessons Learned
    1. Designed experiments with binary responses (pages 5078–5079)

      Keith M. Bower, Abe Germansderfer, Bruce A. Kerwin, Gerd R. Kleemann and Jennifer R. Litowski

      Version of Record online: 5 JUL 2011 | DOI: 10.1002/jps.22699

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