Journal of Pharmaceutical Sciences

Cover image for Vol. 102 Issue 2

February 2013

Volume 102, Issue 2

Pages 303–784

  1. Editorial

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Editorial (page 303)

      Ronald T. Borchardt

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/jps.23407

    2. Editorial (page 304)

      Ronald T. Borchardt

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/jps.23411

  2. Clinical Trials and Translational Medicine Commentaries

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Nanomedicines and nanodiagnostics come of age (pages 305–310)

      Ijeoma F. Uchegbu and Adeline Siew

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/jps.23377

  3. Clinical Trials and Translational Medicine Commentary

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Pharmaceutical cocrystals: The coming wave of new drug substances (pages 311–317)

      Harry G. Brittain

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23402

  4. Commentary

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. You have free access to this content
      Biowaiver monographs for immediate release solid oral dosage forms: Efavirenz (pages 318–329)

      Rodrigo Cristofoletti, Anita Nair, Bertil Abrahamsson, D. W. Groot, Sabine Kopp, Peter Langguth, James E. Polli, Vinod P. Shah and Jennifer B. Dressman

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/jps.23380

  5. Rapid Communications

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Real-time monitoring of thermodynamic microenvironment in a pan coater (pages 336–340)

      Preetanshu Pandey and Dilbir S. Bindra

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23379

    2. Enhanced oral absorption of ibandronate via complex formation with bile acid derivative (pages 341–346)

      Jin Woo Park, Seung Rim Hwang, Ok-cheol Jeon, Hyun Tae Moon and Youngro Byun

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/jps.23413

    3. Effects of submicron particles on formation of micron-sized particles during long-term storage of an interferon-beta-1a solution (pages 347–351)

      Shujun Bai, Yogapriya Murugesan, Milana Vlasic, Lori B. Karpes and Mark L. Brader

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/jps.23414

  6. Drug Discovery-Development Interface

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. In vivo efficacy of enabling formulations based on hydroxypropyl-β-cyclodextrins, micellar preparation, and liposomes for the lipophilic cannabinoid CB2 agonist, MDA7 (pages 352–364)

      Fanny Astruc-Diaz, Steven W. Mcdaniel, Jijun J. Xu, Stéphane Parola, David L. Brown, Mohamed Naguib and Philippe Diaz

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23393

  7. Pharmaceutical Biotechnology

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Effect of antimicrobial preservatives on partial protein unfolding and aggregation (pages 365–376)

      Regina L. Hutchings, Surinder M. Singh, Javier Cabello-Villegas and Krishna M.G. Mallela

      Version of Record online: 20 NOV 2012 | DOI: 10.1002/jps.23362

    2. Salt-induced aggregation of a monoclonal human immunoglobulin G1 (pages 377–386)

      Jonathan Rubin, Lars Linden, Wayne M. Coco, Andreas S. Bommarius and Sven H. Behrens

      Version of Record online: 12 NOV 2012 | DOI: 10.1002/jps.23363

    3. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine (pages 387–400)

      Lei Hu, Sangeeta B. Joshi, Mangala Roshan Liyanage, Mekala Pansalawatta, Mark R. Alderson, Andrea Tate, George Robertson, Jeff Maisonneuve, David B. Volkin and C. Russell Middaugh

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23375

    4. Stability of rituximab in freeze-dried formulations containing trehalose or melibiose under different relative humidity atmospheres (pages 401–414)

      Ville P. Heljo, Vasco Filipe, Stefan Romeijn, Wim Jiskoot and Anne M. Juppo

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23392

    5. Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil–water interfaces (pages 429–440)

      Alana Gerhardt, Kurt Bonam, Jared S. Bee, John F. Carpenter and Theodore W. Randolph

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/jps.23408

    6. Rapid deamidation of recombinant protective antigen when adsorbed on aluminum hydroxide gel correlates with reduced potency of vaccine (pages 454–461)

      Ajit Joseph M. D'Souza, Kevin D. Mar, Joanne Huang, Sumit Majumdar, Brandi M. Ford, Beverly Dyas, Robert G. Ulrich and Vincent J. Sullivan

      Version of Record online: 14 DEC 2012 | DOI: 10.1002/jps.23422

  8. Pharmaceutics, Drug Delivery and Pharmaceutical Technology

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. On the polymorphism of griseofulvin: Identification of two additional polymorphs (pages 462–468)

      Aurelien Mahieu, Jean-francois Willart, Emeline Dudognon, Mark D. Eddleston, William Jones, Florence Danède and Marc Descamps

      Version of Record online: 6 NOV 2012 | DOI: 10.1002/jps.23349

    2. Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps (pages 469–479)

      Noriyasu Kamei, Shingo Kikuchi, Mariko Takeda-Morishita, Yoshiaki Terasawa, Akihito Yasuda, Shuichi Yamamoto, Nobuo Ida, Reiji Nishio and Kozo Takayama

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23364

    3. Injection-molded capsular device for oral pulsatile release: Development of a novel mold (pages 489–499)

      Lucia Zema, Giulia Loreti, Elena Macchi, Anastasia Foppoli, Alessandra Maroni and Andrea Gazzaniga

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23371

    4. Transdermal iontophoretic delivery of propofol: A general anaesthetic in the form of its phosphate salt (pages 500–507)

      Abhishek Juluri, Prabhakar Peddikotla, Michael A. Repka and S Narasimha Murthy

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/jps.23373

    5. Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems (pages 508–517)

      Zsombor Kristóf Nagy, Attlia Balogh, Gábor Drávavölgyi, James Ferguson, Hajnalka Pataki, Balázs Vajna and György Marosi

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23374

    6. Competition of thermodynamic and dynamic factors during formation of multicomponent particles via spray drying (pages 518–529)

      Kohsaku Kawakami, Yusuke Hasegawa, Kenzo Deguchi, Shinobu Ohki, Tadashi Shimizu, Yasuo Yoshihashi, Etsuo Yonemochi and Katsuhide Terada

      Version of Record online: 18 NOV 2012 | DOI: 10.1002/jps.23378

    7. Synthesis of a new pH-sensitive folate–doxorubicin conjugate and its antitumor activity in vitro (pages 530–540)

      Wei-Liang Ye, Zeng-Hui Teng, Dao-Zhou Liu, Han Cui, Miao Liu, Ying Cheng, Tie-Hong Yang, Qi-Bing Mei and Si-Yuan Zhou

      Version of Record online: 20 NOV 2012 | DOI: 10.1002/jps.23381

    8. Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability (pages 541–555)

      Pius Fasinu, Yahya E. Choonara, Riaz A. Khan, Lisa C. Du Toit, Pradeep Kumar, Valence M. K. Ndesendo and Viness Pillay

      Version of Record online: 27 NOV 2012 | DOI: 10.1002/jps.23382

    9. Monitoring of an active coating process for two-layer tablets-model development strategies (pages 556–564)

      Markus Wirges, Adrian Funke, Peter Serno, Klaus Knop and Peter Kleinebudde

      Version of Record online: 27 NOV 2012 | DOI: 10.1002/jps.23383

    10. The biopolymer bacterial nanocellulose as drug delivery system: Investigation of drug loading and release using the model protein albumin (pages 579–592)

      Astrid Müller, Zhixu Ni, Nadine Hessler, Falko Wesarg, Frank A. Müller, Dana Kralisch and Dagmar Fischer

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23385

    11. Development of imiquimod-loaded mucoadhesive films for oral dysplasia (pages 593–603)

      Sandeep K. Ramineni, Larry L. Cunningham Jr., Thomas D. Dziubla and David A. Puleo

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23386

  9. Research Articles

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
  10. Pharmaceutics, Drug Delivery and Pharmaceutical Technology

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Cellulose acetate phthalate microencapsulation and delivery of plasmid DNA to the intestines (pages 617–626)

      Aimi Hanafi, Nadine Nograles, Syahril Abdullah, Mariana Nor Shamsudin and Rozita Rosli

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23389

    2. Hydrogel containing silica shell cross-linked micelles for ocular drug delivery (pages 627–637)

      Changhai Lu, Roshan B. Yoganathan, Michael Kociolek and Christine Allen

      Version of Record online: 30 NOV 2012 | DOI: 10.1002/jps.23390

    3. Effect of substrates on naproxen-polyvinylpyrrolidone solid dispersions formed via the drop printing technique (pages 638–648)

      Hsin-yun Hsu, Scott J. Toth, Garth J. Simpson, Lynne S. Taylor and Michael T. Harris

      Version of Record online: 5 DEC 2012 | DOI: 10.1002/jps.23397

    4. Trehalose preserves the integrity of lyophilized phycoerythrin–antihuman CD8 antibody conjugates and enhances their thermal stability in flow cytometric assays (pages 649–659)

      Corrado Selva, Marco Malferrari, Rossana Ballardini, Alfredo Ventola, Francesco Francia and Giovanni Venturoli

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/jps.23398

    5. Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation (pages 660–673)

      Danny K. Chou, Rajesh Krishnamurthy, Mark Cornell Manning, Theodore W. Randolph and John F. Carpenter

      Version of Record online: 30 NOV 2012 | DOI: 10.1002/jps.23401

    6. Small molecule, big difference: The role of water in the crystallization of paclitaxel (pages 674–683)

      Liana Vella-zarb, Ulrich Baisch and Robert E. Dinnebier

      Version of Record online: 30 NOV 2012 | DOI: 10.1002/jps.23404

    7. Tableting lipid-based formulations for oral drug delivery:A case study with silica nanoparticle–lipid–mannitol hybrid microparticles (pages 684–693)

      Kristen E Bremmell, Angel Tan, Amanda Martin and Clive A Prestidge

      Version of Record online: 14 DEC 2012 | DOI: 10.1002/jps.23406

    8. Ciprofloxacin encapsulation into giant unilamellar vesicles: Membrane binding and release (pages 694–705)

      Nóra Kaszás, Tamás Bozó, Marianna Budai and Pál Gróf

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/jps.23410

    9. Physicochemical characteristics of sunitinib malate and its process-related impurities (pages 706–716)

      Katarzyna Sidoryk, Maura Malińska, Krzysztof Bańkowski, Marek Kubiszewski, Marta Łaszcz, Magdalena Bodziachowska-Panfil, Magdalena Kossykowska, Tomasz Giller, Andrzej Kutner and Krzysztof Woźniak

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/jps.23412

  11. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

    1. Top of page
    2. Editorial
    3. Clinical Trials and Translational Medicine Commentaries
    4. Clinical Trials and Translational Medicine Commentary
    5. Commentary
    6. Rapid Communications
    7. Drug Discovery-Development Interface
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Research Articles
    11. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    12. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    1. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs (pages 741–749)

      Zhixia Qiu, Ning Li, Xin Wang, Fengjie Tian, Qi Liu, Ling Song, Zhen Fan, Yang Lu and Xijing Chen

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23394

    2. An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice (pages 750–760)

      Bianca M. Liederer, Leonid M. Berezhkovskiy, Savita S. Ubhayakar and Yuzhong Deng

      Version of Record online: 5 DEC 2012 | DOI: 10.1002/jps.23395

    3. Determination of functional ABCG2 activity and assessment of drug–ABCG2 interactions in dairy animals using a novel MDCKII in vitro model (pages 772–784)

      Louise Wassermann, Sandra Halwachs, Stefan Lindner, Kerstin U. Honscha and Walther Honscha

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/jps.23399

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