Journal of Pharmaceutical Sciences

Cover image for Vol. 102 Issue 9

Special Issue: DEDICATED TO PROFESSOR LESLIE Z. BENET

September 2013

Volume 102, Issue 9

Pages i–ii, 2889–3467

Issue edited by: Emi Nakashima, Kim Brouwer, Margareta Hammarlund-Udenaes, Tetsuya Terasaki

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      Issue Information (pages i–ii)

      Version of Record online: 12 AUG 2013 | DOI: 10.1002/jps.23702

  2. Commentaries

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      Perspectives on a pharmacokinetics legend: C versus T (contributions over time) (pages 2889–2894 )

      Margareta Hammarlund-Udenaes, Kim Brouwer, Emi Nakashima and Tetsuya Terasaki

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/jps.23628

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    3. You have free access to this content
  3. Editorials

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      Editorial (pages 2909–2909 )

      Ronald T. Borchardt Editor-in-Chief

      Version of Record online: 20 MAY 2013 | DOI: 10.1002/jps.23615

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      Editorial (pages 2910–2911 )

      Ronald T. Borchardt

      Version of Record online: 16 APR 2013 | DOI: 10.1002/jps.23555

  4. Mini Reviews

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      The utility of modeling and simulation in drug development and regulatory review (pages 2912–2923 )

      Shiew-Mei Huang, Darrell R. Abernethy, Yaning Wang, Ping Zhao and Issam Zineh

      Version of Record online: 24 MAY 2013 | DOI: 10.1002/jps.23570

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  5. Reviews

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      Moving from basic toward systems pharmacodynamic models (pages 2930–2940 )

      William J. Jusko

      Version of Record online: 16 MAY 2013 | DOI: 10.1002/jps.23590

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      A pharmacokinetic standard for babies and adults (pages 2941–2952 )

      Nick Holford, Young-A Heo and Brian Anderson

      Version of Record online: 6 MAY 2013 | DOI: 10.1002/jps.23574

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      Plasma protein binding: From discovery to development (pages 2953–2994 )

      Tonika Bohnert and Liang-Shang Gan

      Version of Record online: 24 JUN 2013 | DOI: 10.1002/jps.23614

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      Keeping a critical eye on the science and the regulation of oral drug absorption: A review (pages 3018–3036 )

      Panos Macheras, Vangelis Karalis and Georgia Valsami

      Version of Record online: 8 APR 2013 | DOI: 10.1002/jps.23534

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      An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters (pages 3037–3057 )

      Kyunghee Yang, Kathleen Köck, Alexander Sedykh, Alexander Tropsha and Kim L. R. Brouwer

      Version of Record online: 7 MAY 2013 | DOI: 10.1002/jps.23584

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      Role of Nrf2 in cancer photodynamic therapy: Regulation of human ABC transporter ABCG2 (pages 3058–3069 )

      Toshihisa Ishikawa, Yoshinaga Kajimoto, Wei Sun, Hiroshi Nakagawa, Yutaka Inoue, Yoji Ikegami, Shin-Ichi Miyatake and Toshihiko Kuroiwa

      Version of Record online: 6 MAY 2013 | DOI: 10.1002/jps.23563

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  6. Clinical Trials and Translational Medicine Commentaries

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
    1. You have free access to this content
  7. Pharmaceutical Biotechnology

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies (pages 3089–3099)

      Reza Esfandiary, David B. Hayes, Arun Parupudi, Jose Casas-Finet, Shufeng Bai, Hardeep S. Samra, Ambarish U. Shah and Hasige A. Sathish

      Version of Record online: 21 JUN 2013 | DOI: 10.1002/jps.23654

  8. Pharmaceutics, Drug Delivery and Pharmaceutical Technology

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
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      Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors (pages 3100–3109)

      Daniele Ouellet, Kenneth F. Grossmann, Giselle Limentani, Noelia Nebot, Kevin Lan, Lara Knowles, Michael S. Gordon, Sunil Sharma, Jeffrey R. Infante, Patricia M. Lorusso, Girish Pande, Elizabeth C. Krachey, Samuel C. Blackman and Stanley W. Carson

      Version of Record online: 22 APR 2013 | DOI: 10.1002/jps.23519

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      Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity (pages 3110–3118)

      Noriko Miyakawa, Makiya Nishikawa, Yuki Takahashi, Mitsuru Ando, Masayuki Misaka, Yoshihiko Watanabe and Yoshinobu Takakura

      Version of Record online: 5 MAR 2013 | DOI: 10.1002/jps.23493

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      An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid (pages 3119–3127)

      Yuma Yamada, Masahiro Hashida, Yasuhiro Hayashi, Mai Tabata, Mamoru Hyodo, Mst. Naznin Ara, Noritaka Ohga, Kyoko Hida and Hideyoshi Harashima

      Version of Record online: 7 MAR 2013 | DOI: 10.1002/jps.23480

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      Aminoalkylmethacrylate copolymer E improves oral bioavailability of YM466 by suppressing drug–bile interaction (pages 3128–3135)

      Shigeo Takemura, Hiromu Kondo, Shunsuke Watanabe, Kazuhiro Sako, Ken-ichi Ogawara and Kazutaka Higaki

      Version of Record online: 4 MAR 2013 | DOI: 10.1002/jps.23484

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  9. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
    1. You have free access to this content
      Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux (pages 3145–3160)

      Sibylle Neuhoff, Karen Rowland Yeo, Zoe Barter, Masoud Jamei, David B. Turner and Amin Rostami-Hodjegan

      Version of Record online: 22 MAY 2013 | DOI: 10.1002/jps.23594

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      Application of permeability-limited physiologically-based pharmacokinetic models: Part II - prediction of p-glycoprotein mediated drug–drug interactions with digoxin (pages 3161–3173)

      Sibylle Neuhoff, Karen Rowland Yeo, Zoe Barter, Masoud Jamei, David B. Turner and Amin Rostami-Hodjegan

      Version of Record online: 19 MAY 2013 | DOI: 10.1002/jps.23607

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      Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy (pages 3189–3195)

      Ming-Liang Lai, Yu-En Tien, Ying-Syuan Huang and Jin-Ding Huang

      Version of Record online: 8 MAY 2013 | DOI: 10.1002/jps.23593

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      Utilizing in vitro and PBPK tools to link ADME characteristics to plasma profiles: Case example nifedipine immediate release formulation (pages 3205–3219)

      Christian Wagner, Kirstin Thelen, Stefan Willmann, Arzu Selen and Jennifer B. Dressman

      Version of Record online: 20 MAY 2013 | DOI: 10.1002/jps.23611

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      Disposition kinetics of diclofenac in the dual perfused rat liver (pages 3220–3227)

      Selma Sahin and Malcolm Rowland

      Version of Record online: 23 APR 2013 | DOI: 10.1002/jps.23564

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      Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203 (pages 3228–3238)

      Junko Toyoshima, Hiroyuki Kusuhara, Michael F. Wempe, Hitoshi Endou and Yuichi Sugiyama

      Version of Record online: 27 MAY 2013 | DOI: 10.1002/jps.23601

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      Metabolic characterization of primary rat hepatocytes cultivated in parallel microfluidic biochips (pages 3264–3276)

      Audrey Legendre, Régis Baudoin, Giulia Alberto, Patrick Paullier, Marie Naudot, Thibault Bricks, Jessy Brocheton, Sébastien Jacques, JérôME Cotton and Eric Leclerc

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/jps.23466

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      Metabolism of a serotonin-4 receptor partial agonist 4-{4-[4-tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (TBPT): Identification of an unusual pharmacologically active cyclized oxazolidine metabolite in human (pages 3277–3293)

      Aarti Sawant-Basak, Karen J. Coffman, Gregory S. Walker, Tim F. Ryder, Elaine Tseng, Emily Miller, Carlos Lee, Michelle A. Vanase-Frawley, John W. Wong, Michael A. Brodney, Tracey Rapp and R. Scott Obach

      Version of Record online: 15 APR 2013 | DOI: 10.1002/jps.23542

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      Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties (pages 3294–3301)

      Sumito Ito, Hirotaka Ando, Atsushi Ose, Yoshiaki Kitamura, Tomohiro Ando, Hiroyuki Kusuhara and Yuichi Sugiyama

      Version of Record online: 27 MAY 2013 | DOI: 10.1002/jps.23599

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      Precise comparison of protein localization among OCT, OAT, and MATE in human kidney (pages 3302–3308)

      Hideyuki Motohashi, Yumi Nakao, Satohiro Masuda, Toshiya Katsura, Tomomi Kamba, Osamu Ogawa and Ken-Ichi Inui

      Version of Record online: 29 APR 2013 | DOI: 10.1002/jps.23567

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      Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system (pages 3309–3319)

      Mari Miyajima, Hiroyuki Kusuhara, Kayo Takahashi, Tadayuki Takashima, Takamitsu Hosoya, Yasuyoshi Watanabe and Yuichi Sugiyama

      Version of Record online: 27 MAY 2013 | DOI: 10.1002/jps.23600

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      Oxymorphone active uptake at the blood–brain barrier and population modeling of its pharmacokinetic–pharmacodynamic relationship (pages 3320–3331)

      Muhammad Waqas Sadiq, Emma Boström, Ron Keizer, Sven Björkman and Margareta Hammarlund-Udenaes

      Version of Record online: 5 MAR 2013 | DOI: 10.1002/jps.23492

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      Propranolol Transport Across the Inner Blood–Retinal Barrier: Potential Involvement of a Novel Organic Cation Transporter (pages 3332–3342)

      Yoshiyuki Kubo, Yoshimi Shimizu, Yusuke Kusagawa, Shin-Ichi Akanuma and Ken-Ichi Hosoya

      Version of Record online: 8 APR 2013 | DOI: 10.1002/jps.23535

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      Quantitative atlas of blood–brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset (pages 3343–3355)

      Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Takashi Inoue, Sumio Ohtsuki and Tetsuya Terasaki

      Version of Record online: 6 MAY 2013 | DOI: 10.1002/jps.23575

    19. Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion (pages 3356–3363)

      Tomohiro Nishimura, Tatsuya Takanohashi, Masatoshi Tomi, Miho Horikoshi, Kei Higuchi, Yoshimichi Sai and Emi Nakashima

      Version of Record online: 25 APR 2013 | DOI: 10.1002/jps.23551

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      Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells (pages 3364–3372)

      Kenji Oda, Tomohiro Nishimura, Kei Higuchi, Naomi Ishido, Kaori Ochi, Hisashi Iizasa, Yoshimichi Sai, Masatoshi Tomi and Emi Nakashima

      Version of Record online: 16 APR 2013 | DOI: 10.1002/jps.23549

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      In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice (pages 3373–3381)

      Takeo Nakanishi, Yoshitaka Hasegawa, Tsunemitsu Haruta, Tomohiko Wakayama and Ikumi Tamai

      Version of Record online: 19 MAY 2013 | DOI: 10.1002/jps.23603

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      Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout (pages 3382–3394)

      Ghaith Al-Jayyoussi, Daniel F. Price, Danielle Francombe, Glyn Taylor, Mathew W. Smith, Chris Morris, Chris D. Edwards, Peter Eddershaw and Mark Gumbleton

      Version of Record online: 13 MAY 2013 | DOI: 10.1002/jps.23587

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      Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography–tandem mass spectrometry (pages 3395–3406)

      Atsushi Sakamoto, Takehisa Matsumaru, Norio Yamamura, Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki and Tetsuya Terasaki

      Version of Record online: 13 MAY 2013 | DOI: 10.1002/jps.23606

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      Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin (pages 3407–3417)

      Noritaka Nakamichi, Hiroyo Shima, Satoshi Asano, Takahiro Ishimoto, Tomoko Sugiura, Kazuki Matsubara, Hiroyuki Kusuhara, Yuichi Sugiyama, Yoshimichi Sai, Ken-Ichi Miyamoto, Akira Tsuji and Yukio Kato

      Version of Record online: 10 MAY 2013 | DOI: 10.1002/jps.23595

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      Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions (pages 3418–3426)

      Yoshiyuki Shirasaka, Megumi Shichiri, Takanori Mori, Takeo Nakanishi and Ikumi Tamai

      Version of Record online: 21 JUN 2013 | DOI: 10.1002/jps.23653

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      Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake (pages 3427–3435)

      Yoshihisa Shitara, Kumiko Takeuchi and Toshiharu Horie

      Version of Record online: 25 FEB 2013 | DOI: 10.1002/jps.23477

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  10. Notes

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
    1. You have free access to this content
      A toxicity risk index, an index for warning idiosyncratic drug toxicity (pages 3447–3450 )

      Miyoshi Morimoto, Kazuo Samizo, Shin Ohta and Takashi Mizuma

      Version of Record online: 10 MAY 2013 | DOI: 10.1002/jps.23596

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      Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8) (pages 3451–3457 )

      Sook Wah Yee, Anh Nguyet Nguyen, Chaline Brown, Radojka M. Savic, Youcai Zhang, Richard A. Castro, Cheryl D. Cropp, Ji Ha Choi, Diment Singh, Harunobu Tahara, Sophie L. Stocker, Yong Huang, Claire M. Brett and Kathleen M. Giacomini

      Version of Record online: 6 MAY 2013 | DOI: 10.1002/jps.23581

  11. Lessons Learned

    1. Top of page
    2. Issue Information
    3. Commentaries
    4. Editorials
    5. Mini Reviews
    6. Reviews
    7. Clinical Trials and Translational Medicine Commentaries
    8. Pharmaceutical Biotechnology
    9. Pharmaceutics, Drug Delivery and Pharmaceutical Technology
    10. Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
    11. Notes
    12. Lessons Learned
    1. You have free access to this content
      When is protein binding important? (pages 3458–3467 )

      Jules Heuberger, Stephan Schmidt and Hartmut Derendorf

      Version of Record online: 6 MAY 2013 | DOI: 10.1002/jps.23559

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