Journal of Pharmaceutical Sciences

Copyright © 2012 Wiley Periodicals Inc. and the American Pharmacists Association

Cover image for Journal of Pharmaceutical Sciences

October 2008

Volume 97, Issue 10

Pages 4119–4595

  1. Minireviews

    1. Top of page
    2. Minireviews
    3. Reviews
    4. Commentaries
    5. Research Articles
    1. Heterogeneity in skin treated with low-frequency ultrasound (pages 4119–4128)

      Joseph Kushner IV, Daniel Blankschtein and Robert Langer

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21308

  2. Reviews

    1. Top of page
    2. Minireviews
    3. Reviews
    4. Commentaries
    5. Research Articles
    1. Antiangiogenic drugs: Current knowledge and new approaches to cancer therapy (pages 4129–4154)

      Jose L. Mauriz and Javier González-Gallego

      Article first published online: 15 JAN 2008 | DOI: 10.1002/jps.21286

    2. Measuring and increasing protein solubility (pages 4155–4166)

      Saul R. Trevino, J. Martin Scholtz and C. Nick Pace

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21327

    3. The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics (pages 4167–4183)

      C. Simone Fishburn

      Article first published online: 15 JAN 2008 | DOI: 10.1002/jps.21278

  3. Commentaries

    1. Top of page
    2. Minireviews
    3. Reviews
    4. Commentaries
    5. Research Articles
    1. Your prodrug releases formaldehyde: Should you be concerned? No! (pages 4184–4193)

      Sundeep S. Dhareshwar and Valentino J. Stella

      Article first published online: 20 FEB 2008 | DOI: 10.1002/jps.21319

  4. Research Articles

    1. Top of page
    2. Minireviews
    3. Reviews
    4. Commentaries
    5. Research Articles

    1. Biotechnology

      Preformulation studies of Clostridium difficile toxoids A and B (pages 4194–4207)

      Maya S. Salnikova, Sangeeta B. Joshi, J. Howard Rytting, Michel Warny and C. Russell Middaugh

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21300

    2. Physical stabilization of norwalk virus-like particles (pages 4208–4218)

      Julian Kissmann, Salvador F. Ausar, Thomas R. Foubert, Julie Brock, Mary H. Switzer, Edward J. Detzi, Thomas S. Vedvick and C. Russell Middaugh

      Article first published online: 25 FEB 2008 | DOI: 10.1002/jps.21315

    3. Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab–Fab interaction that impacts solution viscosity (pages 4219–4227)

      Sonoko Kanai, Jun Liu, Thomas W. Patapoff and Steven J. Shire

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21322

    4. Pharmaceutics, Preformulation and Drug Delivery

      Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1 (pages 4228–4239)

      Kavita M. Gupta, Serena M. Pearce, Azadeh E. Poursaid, Hyder A. Aliyar, Patrick A. Tresco, Mark A. Mitchnik and Patrick F. Kiser

      Article first published online: 13 MAR 2008 | DOI: 10.1002/jps.21331

    5. Novel biodegradable blend matrices for controlled drug release (pages 4240–4248)

      Mei Lin, Sheng Meng, Wei Zhong, Zhulai Li, Qiangguo Du and Piotr Tomasik

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21297

    6. The effects of pH and ionic strength on topical delivery of a negatively charged porphyrin (TPPS4) (pages 4249–4257)

      Guilherme Martins Gelfuso, Fábio Vasconcelos Figueiredo, Taís Gratieri and Renata Fonseca Vianna Lopez

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21295

    7. Wide-ranging molecular mobilities of water in active pharmaceutical ingredient (API) hydrates as determined by NMR relaxation times (pages 4258–4268)

      Sumie Yoshioka, Yukio Aso, Tsutomu Osako and Toru Kawanishi

      Article first published online: 6 FEB 2008 | DOI: 10.1002/jps.21294

    8. You have free access to this content
      Compaction of pharmaceutical tablets with different polymer matrices studied by FTIR imaging and X-ray microtomography (pages 4269–4277)

      Patrick Wray, K.L. Andrew Chan, James Kimber and Sergei G. Kazarian

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21309

    9. A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids (pages 4278–4293)

      Marjukka Suhonen, S. Kevin Li, William I. Higuchi and James N. Herron

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21306

    10. Effect of thermodynamic activities of the unionized and ionized species on drug flux across buccal mucosa (pages 4294–4306)

      Amit Kokate, Xiaoling Li, Parminder Singh and Bhaskara R. Jasti

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21301

    11. In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: A novel 5-HT4 partial agonist (pages 4307–4318)

      Satomi Onoue, Naoko Igarashi, Yukinori Yamauchi, Takashi Kojima, Noriaki Murase, Yu Zhou, Shizuo Yamada and Yoshiko Tsuda

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21329

    12. Preparation and characterisation of natamycin: γ-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations (pages 4319–4335)

      Erdal Cevher, Demet Şensoy, Mire Zloh and Lütfiye Mülazımoğlu

      Article first published online: 20 FEB 2008 | DOI: 10.1002/jps.21312

    13. Solid state 13C NMR investigation of impact of annealing in lyophilized glasses (pages 4336–4346)

      Suman A. Luthra, Michael J. Pikal and Marcel Utz

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21316

    14. Shaken, not stirred: Mechanical stress testing of an IgG1 antibody (pages 4347–4366)

      Sylvia Kiese, Astrid Papppenberger, Wolfgang Friess and Hanns-Christian Mahler

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21328

    15. Direct control of drug release behavior from layered double hydroxides through particle interactions (pages 4367–4378)

      Poernomo Gunawan and Rong Xu

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21321

    16. Physicochemical characterization and membrane binding properties of camptothecin (pages 4379–4390)

      Bilge Selvi, Sanjay Patel and Michalakis Savva

      Article first published online: 25 FEB 2008 | DOI: 10.1002/jps.21314

    17. Structure–permeability relationship analysis of the permeation barrier properties of the stratum corneum and viable epidermis/dermis of rat skin (pages 4391–4403)

      Koji Yamaguchi, Tetsuya Mitsui, Yoshinori Aso and Kenji Sugibayashi

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21330

    18. Determination of outer layer and bulk dehydration kinetics of trehalose dihydrate using atomic force microscopy, gravimetric vapour sorption and near infrared spectroscopy (pages 4404–4415)

      Matthew D. Jones, Anthony E. Beezer and Graham Buckton

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21318

    19. Pharmaceutical Nanotechnology

      Direct drug loading into preformed porous solid dosage units by the controlled particle deposition (CPD), a new concept for improved dissolution using SCF-technology (pages 4416–4424)

      Ragna S. Wischumerski, Michael Türk and Martin A. Wahl

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21323

    20. Nanodisks derived from amphotericin B lipid complex (pages 4425–4432)

      Megan Tufteland, Gang Ren and Robert O. Ryan

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21325

    21. Pharmaceutical Technology

      Moisture sorption and permeability characteristics of polymer films: Implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances (pages 4433–4445)

      Enosh Mwesigwa, Abdul W. Basit and Graham Buckton

      Article first published online: 20 FEB 2008 | DOI: 10.1002/jps.21304

    22. Role of mechanical stress in crystallization and relaxation behavior of amorphous indomethacin (pages 4446–4458)

      Chandan Bhugra, Rama Shmeis and Michael J. Pikal

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21291

    23. Atomizing into a chilled extraction solvent eliminates liquid gas from a spray-freeze drying microencapsulation process (pages 4459–4472)

      Michael T. Kennedy, Alana Ali-Reynolds, Christina Farrier and Paul A. Burke

      Article first published online: 6 FEB 2008 | DOI: 10.1002/jps.21290

    24. In situ monitoring of polymorph transformation of clopidogrel hydrogen sulfate using measurement of ultrasonic velocity (pages 4473–4484)

      Hye-Jin Kim and Kwang-Joo Kim

      Article first published online: 31 JAN 2008 | DOI: 10.1002/jps.21313

    25. Quality-by-design (QbD): Effects of testing parameters and formulation variables on the segregation tendency of pharmaceutical powder measured by the ASTM D 6940-04 segregation tester (pages 4485–4497)

      Lin Xie, Huiquan Wu, Meiyu Shen, Larry L. Augsburger, Robbe C. Lyon, Mansoor A. Khan, Ajaz S. Hussain and Stephen W. Hoag

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21320

    26. Different measures of molecular mobility: Comparison between calorimetric and thermally stimulated current relaxation times below Tg and correlation with dielectric relaxation times above Tg (pages 4498–4515)

      Chandan Bhugra, Rama Shmeis, Steven L. Krill and Michael J. Pikal

      Article first published online: 12 FEB 2008 | DOI: 10.1002/jps.21324

    27. Structural, thermodynamic, and kinetic aspects of the trimorphism of hydrocortisone (pages 4516–4527)

      Viktor Suitchmezian, Inke Jeß and Christian Näther

      Article first published online: 13 MAR 2008 | DOI: 10.1002/jps.21334

    28. Pharmacokinetics, Pharmacodynamics and Drug Metabolism

      Pharmacogenomic Profile of Soy Isoflavone Concentrate in the Prostate of Nrf2 Deficient and Wild-Type Mice (pages 4528–4545)

      Avantika Barve, Tin Oo Khor, Sujit Nair, Wen Lin, Siwang Yu, Mohit Raja Jain, Jefferson Y. Chan and Ah-Ng Kong

      Article first published online: 30 JAN 2008 | DOI: 10.1002/jps.21311

    29. Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats (pages 4546–4556)

      Xiaodong Wang and Marilyn E. Morris

      Article first published online: 6 FEB 2008 | DOI: 10.1002/jps.21296

    30. Simulation modelling of human intestinal absorption using Caco-2 permeability and kinetic solubility data for early drug discovery (pages 4557–4574)

      Simon Thomas, Frances Brightman, Helen Gill, Sally Lee and Boris Pufong

      Article first published online: 25 FEB 2008 | DOI: 10.1002/jps.21305

    31. Cellular activation by plasmid DNA in various macrophages in primary culture (pages 4575–4585)

      Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno and Yoshinobu Takakura

      Article first published online: 28 JAN 2008 | DOI: 10.1002/jps.21302

    32. Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding (pages 4586–4595)

      Nigel J. Waters, Rachel Jones, Gareth Williams and Bindi Sohal

      Article first published online: 25 FEB 2008 | DOI: 10.1002/jps.21317

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