Presented as part of a commemorative issue for Wolfgang Kiefer on the occasion of his 65th birthday.
FT-Raman and NIR-SERS characterization of the antimalarial drugs chloroquine and mefloquine and their interaction with hematin†
Article first published online: 12 JAN 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Journal of Raman Spectroscopy
Special Issue: Commemorative Issue: for Wolfgang Kiefer on the Occasion of his 65th Birthday
Volume 37, Issue 1-3, pages 326–334, January - March 2006
How to Cite
Cîntǎ-Pînzaru, S., Peica, N., Küstner, B., Schlücker, S., Schmitt, M., Frosch, T., Faber, J. H., Bringmann, G. and Popp, J. (2006), FT-Raman and NIR-SERS characterization of the antimalarial drugs chloroquine and mefloquine and their interaction with hematin. J. Raman Spectrosc., 37: 326–334. doi: 10.1002/jrs.1471
- Issue published online: 12 JAN 2006
- Article first published online: 12 JAN 2006
- Manuscript Accepted: 1 SEP 2005
- Manuscript Received: 16 JUN 2005
- Deutsche Forschungsgemeinschaft.
- Fonds der Chemischen Industrie.
Raman and surface-enhanced Raman scattering (SERS) spectroscopies were employed to probe the interaction of the antimalarial drugs chloroquine (CQ) and mefloquine (MQ) with hematin. NIR-SERS spectra of both quinoline derivatives were obtained from a colloidal gold surface. Strong chemical interactions of each drug with the Au particles are observed and the similarities of the two NIR-SERS spectra allowed to predict a similar orientation geometry for both of the drugs on the colloidal surface, namely through the quinoline skeletal part of each molecular structure.
Separately, the adsorption behavior of hematin on the Au colloid was studied under nonresonant conditions. In addition, both hematin–antimalarial drug systems (CQ and MQ) were prepared and investigated by NIR-SERS. Copyright © 2006 John Wiley & Sons, Ltd.