Observation of SERS effect in Raman optical activity, a new tool for chiral vibrational spectroscopy


  • Salim Abdali

    Corresponding author
    1. Quantum Protein Centre, QuP, Department of Physics, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
    • QuP, Department of Physics, Building 309, DTU, 2800 Kgs. Lyngby, Denmark.
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A new tool for chiral vibrational spectroscopy is reported here. A surface enhanced effect was observed using Raman optical activity (ROA). This observation opens new possibilities for ROA as a tool for vibrational spectroscopy. The combination of surface enhanced effect (SE) and ROA into surface enhanced Raman optical activity (SEROA) takes this tool to another level, where a single molecule may be studied with respect to chirality, secondary structure and fold determination. ROA has been able to provide information about important dynamics in molecular understanding. Until recently, however, ROA measurements required a longer exposure and higher concentration of the sample. With SEROA these obstacles can be overcome because both studies on single molecule, i.e. very low concentration, and faster acquisition of the signal can be carried out. In the present, work silver colloids were mixed with solution, in which a pentapeptide, Met-Enkephalin, was dissolved. SEROA signals were recorded and the results are reported here. Copyright © 2006 John Wiley & Sons, Ltd.