Rapid Communication

Raman to the limit: tip-enhanced Raman spectroscopic investigations of a single tobacco mosaic virus

  1. Dana Cialla1,
  2. Tanja Deckert-Gaudig2,
  3. Christian Budich2,
  4. Michael Laue3,
  5. Robert Möller1,
  6. Dieter Naumann3,
  7. Volker Deckert2,*,
  8. Jürgen Popp1,4,*

Article first published online: 28 NOV 2008

DOI: 10.1002/jrs.2123

Issue

Journal of Raman Spectroscopy

Journal of Raman Spectroscopy

Volume 40, Issue 3, pages 240–243, March 2009

Additional Information

How to Cite

Cialla, D., Deckert-Gaudig, T., Budich, C., Laue, M., Möller, R., Naumann, D., Deckert, V. and Popp, J. (2009), Raman to the limit: tip-enhanced Raman spectroscopic investigations of a single tobacco mosaic virus. J. Raman Spectrosc., 40: 240–243. doi: 10.1002/jrs.2123

Author Information

  1. 1

    Institute of Physical Chemistry, Friedrich-Schiller-University Jena, Helmholtzweg 4, 07743 Jena, Germany

  2. 2

    Institute for Analytical Sciences (ISAS), Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany

  3. 3

    Robert Koch-Institut (RKI), Nordufer 20, 13353 Berlin-Wedding, Germany

  4. 4

    Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, 07745 Jena, Germany

*Institute for Analytical Sciences (ISAS), Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany.

Publication History

  1. Issue published online: 6 MAR 2009
  2. Article first published online: 28 NOV 2008
  3. Manuscript Accepted: 14 AUG 2008
  4. Manuscript Received: 4 AUG 2008

Funded by

  • Jenaer Biochip Initiative (JBCI)
  • InnoProfile - Unternehmen Region and Mark-erfreie Zelldiagnostik mit Nanometerauflösung. Grant Numbers: 0312032B, 0312032C
  • Federal Ministry of Education and Research(BMBF), Germany

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (190K)

Keywords:

  • TERS;
  • virus;
  • SERS;
  • near-field optics

Abstract

The development of fast identification techniques of viruses is an ongoing important research topic. Conventional virus detection and identification is generally based on various different microbiological methods. However, these techniques are not suitable for the analysis of single virus particles. Therefore, our goal is to establish tip-enhanced Raman scattering (TERS), providing vibrational spectroscopic information with a spatial resolution less than 50 nm, to characterize single viruses at a molecular level. Here we report, to the best of our knowledge for the first time, about TERS spectra of a tobacco mosaic virus, showing the great capability of this technique. However, the application of the TERS technique for a rapid and direct detection of different species of single viruses is under development, which is useful for a wide range of analytical fields. Copyright © 2008 John Wiley & Sons, Ltd.

Get PDF (190K)