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Reference database of Raman spectra of pharmaceutical excipients

  1. Marleen de Veij1,
  2. Peter Vandenabeele2,*,
  3. Thomas De Beer3,
  4. Jean Paul Remon3,
  5. Luc Moens1

Article first published online: 4 NOV 2008

DOI: 10.1002/jrs.2125

Issue

Journal of Raman Spectroscopy

Journal of Raman Spectroscopy

Volume 40, Issue 3, pages 297–307, March 2009

Additional Information

How to Cite

de Veij, M., Vandenabeele, P., De Beer, T., Remon, J. P. and Moens, L. (2009), Reference database of Raman spectra of pharmaceutical excipients. J. Raman Spectrosc., 40: 297–307. doi: 10.1002/jrs.2125

Author Information

  1. 1

    Department of Analytical Chemistry, Ghent University, Proeftuinstraat 86, B-9000 Ghent, Belgium

  2. 2

    Department of Archaeology and Ancient History of Europe, Ghent University, Blandijnberg 2, B-9000 Ghent, Belgium

  3. 3

    Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium

*Department of Archaeology and Ancient History of Europe, Ghent University, Blandijnberg 2, B-9000 Ghent, Belgium.

Publication History

  1. Issue published online: 6 MAR 2009
  2. Article first published online: 4 NOV 2008
  3. Manuscript Accepted: 28 AUG 2008
  4. Manuscript Received: 30 JUN 2008

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Keywords:

  • Raman spectroscopy;
  • excipients;
  • pharmaceuticals;
  • reference Raman spectra

Abstract

Raman spectroscopy has evolved into an important fast, direct and nondestructive technique in pharmaceutical analysis. Usually, the focus in this field is mainly on the active ingredients and not on the excipients present in the drugs. A collection of Raman spectra of widely used pharmaceutical excipients is presented in this article, which can serve as a reference for the interpretation of Raman spectra during drug analysis (including classical qualitative and quantitative pharmaceutical analysis, counterfeit tracing and process analytical technology (PAT) applications). The 43 analyzed excipients can be classified into seven categories: mono- and disaccharides (dextrose, lactitol, maltitol, lactose and sucrose), polysaccharides (microcrystalline cellulose, methylcellulose (MC), carboxymethylcellulose (CMC), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), wheat starch, maltodextrin, primojel, tragacanth and pectin), polyalcohols (propylene glycol, erythritol, xylitol, mannitol and sorbitol), carboxylic acids and salts (alginic acid, glycine, magnesium stearate, sodium acetate and sodium benzoate), esters (arachis oil, lubritab, dibutyl sebacate, triacetin, Eudragit E100 and Eudragit RL100), inorganic compounds (calcium phosphate, talc, anatase and rutile (TiO2), calcium carbonate, magnesium carbonate, sodium bicarbonate and calcium sulfate) and some unclassified products [gelatin, macrogol 4000 (polyethylene glycol (PEG), polyvinyl pyrrolidone and sodium lauryl sulfate]. Copyright © 2008 John Wiley & Sons, Ltd.

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