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Towards a rational drug design: Raman micro-spectroscopy analysis of prostate cancer cells treated with an aqueous extract of Nerium Oleander
Article first published online: 20 APR 2009
DOI: 10.1002/jrs.2302
Copyright © 2009 John Wiley & Sons, Ltd.
1097-4555/asset/cover.gif?v=1&s=d2563a28f6ee44d20c855dfca1ce107304920493 "Journal of Raman Spectroscopy")
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How to Cite
Saha, A. and Yakovlev, V. V. (2009), Towards a rational drug design: Raman micro-spectroscopy analysis of prostate cancer cells treated with an aqueous extract of Nerium Oleander. J. Raman Spectrosc., 40: 1459–1460. doi: 10.1002/jrs.2302
Publication History
- Issue published online: 11 NOV 2009
- Article first published online: 20 APR 2009
- Manuscript Accepted: 2 MAR 2009
- Manuscript Received: 16 DEC 2008
Funded by
- NIH/NIBIB. Grant Number: R03EB008535
- Abstract
- References
- Cited By
Keywords:
- Raman spectroscopy;
- cancer;
- cells;
- microscopy;
- drug design
Abstract
Raman spectroscopy is an efficient optical technique used to identify and grade cancer on the basis of the molecular composition of the cell. In this work Raman spectroscopy is used to study the chemical alteration occurring inside a prostate cancer cell as a result of a treatment with a low-concentration aqueous extract of Nerium Oleander. The results show that Nerium Oleander affects the protein and lipid concentration of cancer cells. Copyright © 2009 John Wiley & Sons, Ltd.