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Application of surface-enhanced Raman scattering in cell analysis

Authors

  • Wei Xie,

    1. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
    2. Department of physics, University of Osnabrueck, 49076 Osnabrueck, Germany
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  • Le Su,

    1. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
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  • Aiguo Shen,

    1. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
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  • Arnulf Materny,

    1. Center of Functional Materials and Nanomolecular Science, Jacobs University Bremen, 28759 Bremen, Germany
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  • Jiming Hu

    Corresponding author
    1. Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
    • Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
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Abstract

In surface-enhanced Raman scattering (SERS), the scattered intensity is drastically increased due to a resonant interaction with surface plasmons of coin metals. SERS is a nondestructive spectroscopic method applied also to biomedical samples. It inherits the advantages of normal Raman spectroscopy and at the same time overcomes the inherent low sensitivity problem. These properties endow SERS with exciting opportunities to be a successful analytical tool for cell analysis. SERS can be used to detect only molecules located on or close to the metallic nanostructures which can support surface plasmon resonances for the enhancement of the Raman signals. Therefore, these metallic nanostructures play a key role in the application of SERS in cell analysis. By incorporating the SERS substrates into the biosamples, molecular structural probing and cellular imaging become possible. In the past decade, analysts worldwide have developed many schemes to study the chemical changes and component distribution in cells by using SERS. In this paper, the application of SERS in cell analysis is reviewed. Copyright © 2011 John Wiley & Sons, Ltd.

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