This paper reports an external fluorescence seeding technology enhancing the stimulated Raman scattering (SRS) in liquid-core optical fiber (LCOF). By surrounding a small section of LCOF with a glass capillary and a solution of Rhodamine 6G filled between them to separate fluorescent dye and Raman medium, the initial intensity of SRS is linearly amplified by external fluorescence seeding, and then the SRS of LCOF can be enhanced effectively. Experimental results show that both the concentration of fluorescent dye and the seeding position have an influence on enhancement of SRS. The maximum enhancement of Stokes lines is obtained when the concentration of dye solution is optimized at ~10−6 mol/l and seeding position is located at the input end. Copyright © 2013 John Wiley & Sons, Ltd.