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Au@SiO2 core/shell nanoparticle assemblage used for highly sensitive SERS-based determination of glucose and uric acid

Authors

  • Tran Thi Bich Quyen,

    1. Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
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  • Wei-Nien Su,

    1. Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan
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  • Kuan-Jung Chen,

    1. Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
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  • Chun-Jern Pan,

    1. Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
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  • John Rick,

    1. Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
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  • Chun-Chao Chang,

    Corresponding author
    1. Taipei Medical University, Taipei, Taiwan
    • Correspondence to: Chun-Chao Chang, Taipei Medical University, Taipei 250, Taiwan.

      E-mail: chunchao@tmu.edu.tw

      Correspondence to: Bing-Joe Hwang, Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.

      E-mail: bjh@mail.ntust.edu.tw

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  • Bing-Joe Hwang

    Corresponding author
    1. Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
    2. National Synchrotron Radiation Research Center, Hsinchu, Taiwan
    • Correspondence to: Chun-Chao Chang, Taipei Medical University, Taipei 250, Taiwan.

      E-mail: chunchao@tmu.edu.tw

      Correspondence to: Bing-Joe Hwang, Nanoelectrochemistry Laboratory, Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.

      E-mail: bjh@mail.ntust.edu.tw

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Abstract

The use of Au@SiO2 core/shell nanoparticle (NP) assemblage with highly sensitive surface-enhanced Raman scattering (SERS) was investigated for the determination of glucose and uric acid in this study. Rhodamine 6G dye molecules were used to evaluate the SERS enhancement factor for the synthesized Au@SiO2 core/shell NPs with various silica shell thicknesses. The enhancement of SERS signal from Rhodamine 6G was found to increase with a decrease in the shell thickness. The core/shell assemblage with silica layer of 1–2 nm over a Au NP of ~36 nm showed the highest SERS signal. Our results show that the SERS technique is able to detect glucose and uric acid within wide concentration ranges, i.e. 20 ng/dL to 20 mg/dL (10−12–10−3 M) and 16.8 ng/dL to 2.9 mg/dL (10−11–1.72 × 10−4 M), respectively, with associated lower detection limits of ~20 ng/dL (~1.0 × 10−12 M) and ~16.8 ng/dL (~1.0 × 10−11 M). Our work offers a low-cost route to the fabrication of agile sensing devices applicable to the monitoring of disease progression. Copyright © 2013 John Wiley & Sons, Ltd.

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