Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using Raman molecular imaging
Article first published online: 16 MAR 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Journal of Raman Spectroscopy
Volume 45, Issue 4, pages 274–280, April 2014
How to Cite
Stewart, S., Kirschner, H., Treado, P. J., Priore, R., Tretiakova, M. and Cohen, J. K. (2014), Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using Raman molecular imaging. J. Raman Spectrosc., 45: 274–280. doi: 10.1002/jrs.4460
- Issue published online: 6 APR 2014
- Article first published online: 16 MAR 2014
- Manuscript Accepted: 13 FEB 2014
- Manuscript Revised: 11 FEB 2014
- Manuscript Received: 17 SEP 2013
- kidney cancer;
- Raman imaging;
Raman molecular imaging was evaluated as a tool for differentiating between kidney tumors which are sometimes confused using conventional histopathological methods.
Renal oncocytoma and chromophobe renal cell carcinoma are two kidney tumors which occasionally possess overlapping histological features. There is no reliable alternative method to routine histologic examination for differentiating these neoplasms. However, a conclusive diagnosis is important, as renal oncocytoma is benign and chromophobe renal cell carcinoma has malignant potential, requiring different treatment options.
In an investigation based on 88 patients, a partial least squares discriminant analysis model generated from Raman molecular images distinguished between chromophobe renal cell carcinoma and renal oncocytoma with a performance of 86% sensitivity and 81% specificity.
These initial observations suggest that Raman molecular imaging may be applied not only to the differentiation of these kidney tumors but also to other applications for which conventional histological methods are not sufficient for a conclusive diagnosis. Copyright © 2014 John Wiley & Sons, Ltd.