In many scientific disciplines, systematic reviews and meta-analyses are increasingly indispensable as summaries of the evidence in relation to a particular phenomenon, making it ever more important for scientists to know how best to review evidence. Khan, Kunz, Kleijnen, and Antes's Systematic Reviews to Support Evidence-Based Medicine (2nd edition, 2011, CRC Press, ISBN-13: 9781853157943) provides a fine, brief introduction to the subject, in particular for those in medicine and public health fields. Our review details strengths of this book, such as its conciseness and clarity and its close match to current conventions in systematic reviewing. We also discuss nuances of the subject that might augment a future edition or lead readers to other resources. In doing so, these discussions also address how present practices in systematic reviewing might improve. Copyright © 2013 John Wiley & Sons, Ltd.