Research Article

Honey-bee products in prevention and/or therapy of murine transplantable tumours

  1. Nada Oršolić1,*,
  2. Svjetlana Terzić2,
  3. Lidija Šver3,
  4. Ivan Bašić1

Article first published online: 3 DEC 2004

DOI: 10.1002/jsfa.2041

Issue

Journal of the Science of Food and Agriculture

Journal of the Science of Food and Agriculture

Volume 85, Issue 3, pages 363–370, February 2005

Additional Information

How to Cite

Oršolić, N., Terzić, S., Šver, L. and Bašić, I. (2005), Honey-bee products in prevention and/or therapy of murine transplantable tumours. Journal of the Science of Food and Agriculture, 85: 363–370. doi: 10.1002/jsfa.2041

Author Information

  1. 1

    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia

  2. 2

    Croatian Veterinary Institute, Savska c 143, Zagreb, Croatia

  3. 3

    Laboratory for Biology and Microbial Genetics, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia

*Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia

Publication History

  1. Issue published online: 4 JAN 2005
  2. Article first published online: 3 DEC 2004
  3. Manuscript Accepted: 28 JUN 2004
  4. Manuscript Revised: 13 JUN 2004
  5. Manuscript Received: 19 JAN 2004

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Keywords:

  • honey;
  • bee venom;
  • propolis;
  • royal jelly;
  • caffeic acid;
  • tumours;
  • metastasis

Abstract

We investigated the effects of water-soluble derivative of propolis (WSDP), caffeic acid, honey, royal jelly and bee venom on tumour development and metastasis in murine tumour models. Transplantable murine tumours were used: a spontaneous mammary carcinoma (MCa) and a methylcholanthrene–induced fibrosarcoma (FS) of CBA mouse. Metastases in the lung were generated by injecting 105 or 2 × 105 viable tumour cells intravenously. Tumours in the hind leg were generated by subcutaneous injection of 104 or 105 mammary carcinoma cells. Oral application of WSDP or caffeic acid significantly reduced subcutaneous tumour growth and prolonged survival of mice. Honey also exerted a pronounced antimetastatic effect (p < 0.01 or p < 0.001) when applied before tumour cell inoculation (2 g kg−1 orally once a day for 10 consecutive days). Royal jelly did not affect the formation of metastases when given intraperitoneally or subcutaneously. However, synchronous application of tumour cells and royal jelly intravenously significantly (p < 0.001) inhibited the formation of metastases. When bee venom was injected intratumourally, tumours decreased in size. These findings demonstrated that honey-bee products given orally or systemically may have an important role controlling tumour growth and metastasis. Copyright © 2004 Society of Chemical Industry

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