Immunomodulatory activities and antioxidant properties of polysaccharides from Monascus-fermented products in vitro
Article first published online: 5 DEC 2011
Copyright © 2011 Society of Chemical Industry
Journal of the Science of Food and Agriculture
Volume 92, Issue 7, pages 1483–1489, May 2012
How to Cite
Tseng, K.-C., Fang, T. J., Chiang, S.-S., Liu, C.-F., Wu, C.-L. and Pan, T.-M. (2012), Immunomodulatory activities and antioxidant properties of polysaccharides from Monascus-fermented products in vitro. J. Sci. Food Agric., 92: 1483–1489. doi: 10.1002/jsfa.4731
- Issue published online: 4 APR 2012
- Article first published online: 5 DEC 2011
- Manuscript Accepted: 29 SEP 2011
- Manuscript Revised: 29 JUL 2011
- Manuscript Received: 13 JUN 2011
- Raw 264.7 cell;
BACKGROUND:Monascus-fermented products have featured in Chinese cuisine for thousands of years and are widely used as food colourants and dietary materials in many Asian countries. Rice and dioscorea fermented with Monascus purpureus NTU 568 have health-promoting attributes in vitro and in vivo. The aim of this study was to investigate the immunomodulatory and antioxidant effects of polysaccharides from red mould rice (RMRP) and red mould dioscorea (RMDP) in Raw 264.7 cells.
RESULTS: The results showed the antioxidant capabilities (including scavenging, chelating, inhibition of lipid peroxidation, and reducing power) of RMRP and RMDP at a concentration of 10 mg mL−1. RMRP and RMDP also stimulated cell proliferation, nitric oxide production, phagocytosis and cytokine production (including IL1-β, IL-6 and TNF-α) in Raw 264.7 cells.
CONCLUSION: These findings demonstrate that RMRP and RMDP have antioxidant and immunomodulation potential to be developed as novel dietary supplements. Copyright © 2011 Society of Chemical Industry