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Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage

Authors

  • Loıc Lenoir,

    1. Laboratoire de Pharmacognosie et Phytothérapie, Clermont Université, Université d'Auvergne, EA 4233, BP 10448, F-63000 Clermont-Ferrand, France
    2. 3inature BIOSPHERE, Le Naturopôle, F-03800 Saint-Bonnet-de-Rochefort, France
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  • Juliette Joubert-Zakeyh,

    1. CHU Clermont-Ferrand, Service d'Anatomie et de Cytologie Pathologiques, F-63003 Clermont-Ferrand, France
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  • Odile Texier,

    1. Laboratoire de Pharmacognosie et Phytothérapie, Clermont Université, Université d'Auvergne, EA 4233, BP 10448, F-63000 Clermont-Ferrand, France
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  • Jean-Louis Lamaison,

    1. Laboratoire de Pharmacognosie et Phytothérapie, Clermont Université, Université d'Auvergne, EA 4233, BP 10448, F-63000 Clermont-Ferrand, France
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  • Marie-Paule Vasson,

    1. Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Clermont Université, Université d'Auvergne, EA 4233, BP 10448, F-63000 Clermont-Ferrand, France
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  • Catherine Felgines

    Corresponding author
    1. Laboratoire de Pharmacognosie et Phytothérapie, Clermont Université, Université d'Auvergne, EA 4233, BP 10448, F-63000 Clermont-Ferrand, France
    • Laboratoire de Pharmacognosie et Phytothérapie, Faculté de Pharmacie, 28 Place Henri Dunant, BP 38, F-63001 Clermont-Ferrand Cedex 1, France.
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Abstract

BACKGROUND: Inflammatory bowel diseases consist of uncontrolled intestinal inflammation leading to mucosal disruption. Polyphenols are micronutrients with antioxidant and anti-inflammatory properties and may play an interesting role in the prevention of intestinal inflammation. Lemon verbena (Aloysia triphylla (L'Herit.) Britton, Verbenaceae) infusion is a popular herbal drink rich in polyphenols. This study evaluated the protective effects of lemon verbena infusion consumption on the development of dextran sulfate sodium (DSS)-induced colitis in rats. The infusion was given to rats as a drink providing 82 µmol polyphenols day−1 for 21 days. Colitis was induced with 40 g l−1 DSS in the drink for the last 7 days.

RESULTS: Lemon verbena infusion treatment restored body weight gain and prevented colonic shortening. Despite no protective effect on myeloperoxidase activity, A. triphylla infusion limited histological colonic alterations.

CONCLUSION: The results suggest that lemon verbena infusion partially protects rats against DSS-induced inflammation. Copyright © 2011 Society of Chemical Industry

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