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Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting

Authors

  • Atsushi Sano,

    Corresponding author
    1. Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba 278-0037, Japan
      Atsushi Sano, Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba 278-0037, Japan. E-mail: asano@mail.kikkoman.co.jp
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  • Shoichi Tokutake,

    1. Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba 278-0037, Japan
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  • Akihiko Seo

    1. Department of Management Systems Engineering, Faculty of System Design, Tokyo Metropolitan University, 6-6 Asahigaoka, Hino, Tokyo 191-0065, Japan
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Atsushi Sano, Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba 278-0037, Japan. E-mail: asano@mail.kikkoman.co.jp

Abstract

BACKGROUND: Leg swelling is a modern-day affliction of sedentary working women. The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.

RESULTS: Single intake trials and 14 day intake trials were held in a double-blind, placebo-controlled, crossover clinical study. A prolonged sedentary position was maintained for 6 h after GSE or placebo administration. Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.

CONCLUSION: The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting. © 2012 Society of Chemical Industry

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