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Anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extract in high-fat diet-induced obese rats

Authors

  • Qin Li,

    1. Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Hunan, People's Republic of China
    2. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Zhonghua Liu,

    Corresponding author
    1. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
    2. Department of Chemistry, Tsinghua University and Key Laboratory of Biological Organic Phosphorus and Chemical Biology of Ministry of Education, Beijing, People's Republic of China
    • Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Hunan, People's Republic of China
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  • Jianan Huang,

    1. Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Hunan, People's Republic of China
    2. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Guoan Luo,

    Corresponding author
    1. Department of Chemistry, Tsinghua University and Key Laboratory of Biological Organic Phosphorus and Chemical Biology of Ministry of Education, Beijing, People's Republic of China
    • Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Hunan, People's Republic of China
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  • Qionglin Liang,

    1. Department of Chemistry, Tsinghua University and Key Laboratory of Biological Organic Phosphorus and Chemical Biology of Ministry of Education, Beijing, People's Republic of China
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  • Die Wang,

    1. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Xiaoyan Ye,

    1. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Chaobi Wu,

    1. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Lili Wang,

    1. National Research Center of Engineering and Technology, Utilization of Botanical Functional Ingredients, Hunan, People's Republic of China
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  • Jiehui Hu

    1. AB Sciex, Asia Pacific Application Support Center, Shanghai, People's Republic of China
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Correspondence to: Zhonghua Liu, Key Laboratory of Tea Science of Ministry of Education and Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Changsha, Hunan 410128, China. E-mail: larkin-liu@163.com

Guoan Luo, Department of Chemistry, Tsinghua University and Key Laboratory of Biological Organic Phosphorus and Chemical Biology of Ministry of Education, Beijing, 100084, People's Republic of China. E-mail: luoga@mail.tsinghua.edu.cn

Abstract

Background

Fuzhuan brick tea is a kind of microbial fermented tea, which has received increasing attention in recent years owing to its benefits for human health. In this study, the anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extracts (FTEs) were investigated.

Results

FTEs consisted of 204.07 ± 3.38 mg g−1 polyphenol, 109.20 ± 1.36 mg g−1 flavonoids, and others. The FTEs significantly suppressed the increase of body weight and accumulation of adipose tissue, and reduced the level of serum triacylglycerol, total cholesterol and low-density lipoprotein (LDL) cholesterol in obese rats fed a high-fat diet. Moreover, FTEs attenuated the gene expression of sterol regulatory element binding protein-1c, fatty acid synthase and CCAAT/enhancer binding protein α, which is related to lipogenic metabolism. In contrast, the gene expressions of enzymes involved in energy expenditure and lipodieresis including hepatic peroxisome proliferator-activated receptor α, carnitine palmitoyltransferase 1a and LDL receptor gene expression were increased by FTE treatment.

Conclusions

Our study demonstrates that FTEs have anti-obesity and hypolipidemic functions, suggesting that it might be effective for treatment of obesity and hyperlipemia.

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