High-mobility group protein 1(Y): Metastasis-associated or metastasis-inducing?

Authors

  • Alice Evans BMedSci(Hons), MBBS, MRCS(Ed),

    Corresponding author
    1. School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, United Kingdom
    • School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, NE2 4HH, UK. Fax: +441912228514.
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  • Thomas W.J. Lennard FRCS, MD,

    1. School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, United Kingdom
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  • Barry R. Davies BSc, PhD

    1. School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, United Kingdom
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Abstract

Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis. J. Surg. Oncol. 2004;88:86–99. © 2004 Wiley-Liss, Inc.

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