High-mobility group protein 1(Y): Metastasis-associated or metastasis-inducing?
Article first published online: 21 OCT 2004
Copyright © 2004 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 88, Issue 2, pages 86–99, 1 November 2004
How to Cite
Evans, A., Lennard, T. W.J. and Davies, B. R. (2004), High-mobility group protein 1(Y): Metastasis-associated or metastasis-inducing?. J. Surg. Oncol., 88: 86–99. doi: 10.1002/jso.20136
- Issue published online: 21 OCT 2004
- Article first published online: 21 OCT 2004
- Manuscript Accepted: 9 AUG 2004
- Newcastle Healthcare Charity, Newcastle-upon-Tyne
Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis. J. Surg. Oncol. 2004;88:86–99. © 2004 Wiley-Liss, Inc.