The biologic significance of micrometastatic disease and sentinel lymph node technology on colorectal cancer

Authors

  • Douglas Iddings DO,

    1. Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California
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  • Anton Bilchik MD, PhD

    Corresponding author
    1. Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California
    • John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404. Fax 310-449-5261.
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  • Disclosure: The authors have no affiliations or financial interests to disclose.

Abstract

The sentinel lymph node (SLN) technique has practical applications in multiple solid tumors including colorectal carcinoma. Identifying the SLN(s) provides better staging of the regional lymphatics beyond standard H&E analysis. This additional information assists in predicting biology and may be useful in guiding adjuvant therapy. We postulate the era of sentinel node has ushered in a new generation of node-negative patients; patients that have an exceptionally favorable outcome when compared to historic controls. J. Surg. Oncol. 2007;96:671–677. © 2007 Wiley-Liss, Inc.

Ancillary