Neoadjuvant therapy for breast cancer
Article first published online: 24 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: Seminars in Surgical Oncology: Neoadjuvant Therapy for Locally Advanced Cancer
Volume 101, Issue 4, pages 283–291, 15 March 2010
How to Cite
Liu, S. V., Melstrom, L., Yao, K., Russell, C. A. and Sener, S. F. (2010), Neoadjuvant therapy for breast cancer. J. Surg. Oncol., 101: 283–291. doi: 10.1002/jso.21446
- Issue published online: 24 FEB 2010
- Article first published online: 24 FEB 2010
- Manuscript Accepted: 30 SEP 2009
- Manuscript Received: 28 SEP 2009
- breast cancer;
- neoadjuvant therapy;
- sentinel node;
The past few decades have seen an increase in both the role and the complexity of neoadjuvant therapy for breast cancer. Neoadjuvant therapy was initially described as systemic chemotherapy for inflammatory or locally advanced breast cancer but now entails a combination of chemotherapy, endocrine therapy, and targeted therapy. Neoadjuvant systemic therapy is employed for inoperable inflammatory and locally advanced breast cancer, and also for patients with operable breast cancers who desire breast-conserving therapy (BCT) but are not candidates based on the initial size of the tumor in relation to the size of the breast. Neoadjuvant therapy in this subset of patients may impact the surgical options. This review will summarize the benefits of neoadjuvant systemic therapy and implications for BCT, the timing of sentinel node biopsy, and the utility of magnetic resonance imaging (MRI) to predict response to therapy. J. Surg. Oncol. 2010; 101:283–291. © 2010 Wiley-Liss, Inc.