1096-9098/asset/JSO_centre.gif?v=1&s=b44eca97c40499f32ff14e6985e50766d4683ad2)
Research Article
Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer
Article first published online: 29 JAN 2010
DOI: 10.1002/jso.21495
Copyright © 2010 Wiley-Liss, Inc.
1096-9098/asset/cover.gif?v=1&s=96beda43b18df3cd9e0fc6722e6240cd02a846a1 "Journal of Surgical Oncology")
Additional Information
How to Cite
Huh, J. W., Oh, B. R., Kim, H. R. and Kim, Y. J. (2010), Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer. J. Surg. Oncol., 101: 396–400. doi: 10.1002/jso.21495
Publication History
- Issue published online: 26 MAR 2010
- Article first published online: 29 JAN 2010
- Manuscript Accepted: 30 NOV 2009
- Manuscript Received: 7 OCT 2009
Funded by
- Chonnam National University Research Institute of Medical Sciences
- Abstract
- References
- Cited By
Keywords:
- carcinoembryonic antigen;
- prognosis;
- colon cancer
Abstract
Objective
We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colon cancer.
Methods
We reviewed 474 patients who underwent potentially curative resection for nonmetastatic colon cancer. Patients were categorized into two groups according to the preoperative serum CEA level: low CEA (<5 ng/ml) and high CEA (≥5 ng/ml) groups.
Results
During the median 45-month follow-up period, the 5-year overall and disease-free survival rates for patients with a low CEA level were 81.7% and 82.4%, respectively, which were significantly higher than the rates for those with a high CEA level (69.9%; P = 0.011 and 70.6%; P = 0.002, respectively). A multivariate analysis revealed that a preoperative serum CEA level was a significant independent prognostic factor for both overall survival (P = 0.021) and disease-free survival (P = 0.026). Both the overall and disease-free survival rates in patients with stage II tumors differed significantly between the low and high CEA groups, whereas the rates did not different between those with stage I and III tumors.
Conclusions
Preoperative serum CEA is a reliable predictor of recurrence and survival after curative surgery in patients with colon cancer, particularly in those classified as having stage II disease. J. Surg. Oncol. 2010; 101:396–400. © 2010 Wiley-Liss, Inc.