Use of sentinel lymph node biopsy for melanoma in children and adolescents
Article first published online: 18 AUG 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 102, Issue 6, pages 634–639, 1 November 2010
How to Cite
Raval, M. V., Bilimoria, K. Y., Bentrem, D. J., Stewart, A. K., Ko, C. Y., Reynolds, M. and Wayne, J. D. (2010), Use of sentinel lymph node biopsy for melanoma in children and adolescents. J. Surg. Oncol., 102: 634–639. doi: 10.1002/jso.21683
- Issue published online: 22 OCT 2010
- Article first published online: 18 AUG 2010
- Manuscript Accepted: 25 JUN 2010
- Manuscript Received: 9 APR 2010
- John Gray Research Fellowship by the Daniel F. and Ada L. Rice Foundation
- Priority Grant
- Career Development Award
- sentinel lymph node biopsy;
- pediatric oncology;
- pediatric surgery;
- National Cancer Data Base
Though sentinel lymph node biopsy (SLNB) is an integral component of melanoma staging, little is known about its use in children.
Patients (0–18 years) with melanoma diagnosed from 2003 to 2007 in the National Cancer Data Base were assessed. Logistic regression models were used to identify clinicopathologic, socioeconomic, and hospital factors associated with SLNB use and lymph node metastases (LNM).
Of 671 children, 68.7% underwent SLNB. SLNB utilization rates were 39.9% for T1a patients and 87.6% for T1b–T3 patients. T1b–T3 patients were more likely to undergo SLNB if they were older (OR 4.86 95% CI: 1.88–12.59) or cared for at Children's hospitals (OR 2.43 95% CI: 1.09–5.40). T1b–T3 patients were less likely to undergo SLNB if uninsured (OR 0.25 95% CI: 0.08–0.76). Of those with SLNB, 118 (25.6%) had pathologically confirmed LNM. Patients were more likely to have LNM if younger (OR 3.19 95% CI: 1.20–8.51) or having higher T stage (OR 10.38 95% CI: 4.59–23.47).
SLNB use for children with melanoma was associated with clinicopathologic, socioeconomic, and hospital factors. Younger patients have a higher likelihood of LNM but are the least likely to undergo SLNB. Though overall adherence appears high, there remains an opportunity for improved care for children with melanoma. J. Surg. Oncol. 2010;102:634–639. © 2010 Wiley-Liss, Inc.