The authors have no disclosures related to the subject matter discussed in this paper.
Article first published online: 7 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: The Pivotal Role of the Lymphovascular System in Cancer Metastasis
Volume 103, Issue 6, pages 508–517, 1 May 2011
How to Cite
Hoon, D. S.B., Ferris, R., Tanaka, R., Chong, K. K., Alix-Panabières, C. and Pantel, K. (2011), Molecular mechanisms of metastasis. J. Surg. Oncol., 103: 508–517. doi: 10.1002/jso.21690
These studies were presented at 3rd International Symposium on Cancer Metastasis and the Lymphovascular System: Basis for Rational Therapy, UCSF, San Francisco, CA, May 2009.
- Issue published online: 7 APR 2011
- Article first published online: 7 APR 2011
- Manuscript Accepted: 12 JUL 2010
- Manuscript Received: 1 JUL 2010
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Melanoma Research Alliance. Grant Number: R01 115902
- National Institutes of Health, National Cancer Institute
- chemokine receptor;
The mechanism of metastasis is a complex set of events that build upon each other to achieve successful growth in organ sites beyond the primary tumor. The cumulative events for metastasis of different cancers have both common and specific cancer specific events. This review discusses several key factors in different cancers that are responsible in metastasis, which includes epigenetic regulation of tumor suppressor genes, functional activity of tumor-related chemokine receptors, and circulating tumor cells. J. Surg. Oncol. 2011;103:508–517. © 2011 Wiley-Liss, Inc.