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Immune response to cancer and its regulation in regional lymph nodes


  • Rongxiu Zheng MD,

    1. Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, People's Republic of China
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  • Suyu Shu PhD

    Corresponding author
    1. Providence Cancer Center, Laboratory of Molecular and Tumor Immunology, Portland, Oregon
    • Laboratory of Molecular and Tumor Immunology, Providence Cancer Center, 4805 NE Glisan Street, North Pavilion, 2N58, Portland, OR 97213. Fax: 503-215-6841.
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Regional draining lymph nodes (LNs) play a pivotal role in initiating immune responses. However, the presence of metastases may compromise their normal immunological function. Preclinical studies indicate that despite metastases, early tumor-draining LNs are still a rich source of sensitized T cells. Recently, we found that dendritic (DC)-tumor fusion hybrids were capable of stimulating therapeutic T-cell generation in the LN. However, this response is regulated by a tumor-specific suppression mechanism(s). Reversal of these dysfunctions would help the success of immunotherapy. J. Surg. Oncol. 2011;103:550–554. © 2011 Wiley-Liss, Inc.